Evidence map›Paper›PMID 28450301›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma.

Junji Egawa, Jan M Schilling, Weihua Cui, Edmund Posadas, Atsushi Sawada, Basheer Alas, Alice E Zemljic-Harpf, McKenzie J Fannon-Pavlich, Chitra D Mandyam, David M Roth and 3 more

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Astrocytic FABP7 Alleviates Depression-Like Behaviors of Chronic Unpredictable Mild Stress Mice by Regulating Neuroinflammation and Hippocampal Spinogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Neuron-targeted caveolin-1 improves neuromuscular function and extends survival in SOD1FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  12. Article
  13. Review
  14. Article
  15. Caveolins as Regulators of Stress Adaptation.Molecular pharmacology · 2018
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Junji EgawaVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
Jan M SchillingVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
Weihua CuiVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
Edmund PosadasVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
Atsushi SawadaVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
Basheer AlasVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
Alice E Zemljic-HarpfVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
McKenzie J Fannon-PavlichVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
Chitra D MandyamVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
David M RothVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
Hemal H PatelVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
Piyush M PatelVeterans Affairs San Diego Healthcare System, San Diego, California, USA.
Brian P HeadVeterans Affairs San Diego Healthcare System, San Diego, California, USA; bhead@ucsd.edu.
VA San Diego Healthcare System · USUniversity of California, San Diego · USNara Medical University · JP

Funding

Vector Production CoreP01HL066941 · NHLBI · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI HAMMOND, H. KIRK · 2001 to 2017
$34.8M
Caveolae, mitochondria, and cardiac protection.R01HL091071 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATEL, HEMAL H · 2008 to 2019
$3.8M
Integrins and Caveolin Proteins in Cardiac Hypertrophy and FailureR01HL115933 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSS, ROBERT SCOTT, ROTH, DAVID M · 2013 to 2016
$2.6M
The Role of RhoGTPases in Anesthetic-Mediated NeurotoxicityR01GM085179 · NIGMS · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI PATEL, PIYUSH M · 2010 to 2019
$2.3M
Protection of the Aged MyocardiumR01HL107200 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATEL, HEMAL H, ROTH, DAVID M · 2011 to 2014
$2.1M
Methamphetamine and Adult Hippocampal NeurogenesisR01DA034140 · NIDA · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI MANDYAM, CHITRA D · 2013 to 2017
$1.4M
Neuronal-targeted caveolin-1 as a therapy for traumatic brain injuryR01NS073653 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEAD, BRIAN P · 2012 to 2015
$1.4M
Caveolin-Mediated Neuroplasticity in Alzheimer's Disease and in Human Neurons Harboring EOFAD MutationsI01BX003671 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI HEAD, BRIAN P · 2017 to 2024
–
Novel Therapeutics for Diabetic CardiomyopathyI01BX001963 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI PATEL, HEMAL H · 2013 to 2025
–
Neuron-Targeted Caveolin-1 as a Therapy for Age-Related NeurodegenerationI01BX001225 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI HEAD, BRIAN P · 2012 to 2014
–
Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.I01BX000783 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI ROTH, DAVID M · 2011 to 2019
–
BLRD VA I01 BX000783BLRD VA I01 BX001225BLRD VA I01 BX001963BLRD VA I01 BX003671NHLBI NIH HHS P01 HL066941NHLBI NIH HHS R01 HL091071NHLBI NIH HHS R01 HL107200NHLBI NIH HHS R01 HL115933NIDA NIH HHS R01 DA034140NIGMS NIH HHS R01 GM085179NINDS NIH HHS R01 NS073653
6 · The paper itself

Abstract

Studies

Indexed as

AnimalsBrain Injuries, TraumaticCaveolin 1Conditioning, PsychologicalFearGene Expression RegulationGenetic TherapyGenotypeMaleMemoryMiceMice, Inbred C57BLMice, TransgenicNeuronal PlasticityNeuronsCaveolin 1fear conditioninghippocampusinverted gridMLRsneuroprotection

Identifiers

PMID28450301
PMCPMC5503707
OpenAlexW2609547362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.