ArticleExperimental hematology2017
Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo.
Article in Experimental hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Hematopoietic stem cell-independent and -dependent hematopoiesis: new insights and lineage-tracing methods.Experimental hematology · 2026Review
- Endothelial heterogeneity in bone marrow: insights across development, adult life and leukemia.Leukemia · 2025Review
- Article
- Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression.Nature communications · 2023Article
- Engineering T Cell Development for the Next Generation of Stem Cell-Derived Immunotherapies.GEN biotechnology · 2023Review
- Review
- Article
- Transcriptional reprogramming in neonatal hematopoietic stem and progenitor cells.Experimental hematology · 2021Review
- Arterial endothelium creates a permissive niche for expansion of human cord blood hematopoietic stem and progenitor cells.Stem cell research & therapy · 2020Article
- Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells.Cell reports · 2020Article
- Chasing Mavericks: The quest for defining developmental waves of hematopoiesis.Current topics in developmental biology · 2019Review
- Cells with hematopoietic potential reside within mouse proepicardium.Histochemistry and cell biology · 2018Article
- Many layers of embryonic hematopoiesis: new insights into B-cell ontogeny and the origin of hematopoietic stem cells.Experimental hematology · 2018Review
- Cell cycle dynamics and complement expression distinguishes mature haematopoietic subsets arising from hemogenic endothelium.Cell cycle (Georgetown, Tex.) · 2017Article
- Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Hematopoietic stem and progenitor cells (HSPCs) sustain life-long hematopoiesis and are first detected in the embryo by transplantation at embryonic day 10.5 (E10.5). HSPCs are mesodermal in origin and ultimately emerge from a subset of arterial endothelium (i.e., hemogenic endothelium [HE]), which is highly concentrated in the aorta-gonad-mesonephros region of the midgestation embryo. Here, we used clonal ex vivo assays, in which endothelial cells isolated from the midgestation aorta and vitelline and umbilical arteries are co-cultured on supportive stroma, to show that only about 0.1%, 1.3%, and 0.29% of E9.5, E10.5, and E11.5 endothelium are functional HE, respectively. We further show high phenotypic and functional variability in the hematopoietic potential of individual hemogenic endothelial precursors. Using unique niche stroma capable of providing the signals necessary for definitive hematopoietic stem cell (dHSC) induction, we demonstrate that this variability in HE includes their potential to support phenotypic dHSCs. These data suggest the presence of a continuum of maturing HE with distinct hematopoietic potential or HE representative of a heterogeneous pool of precursors that give rise to HSPCs with disparate hematopoietic potential.
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Registered trials
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