Evidence map›Paper›PMID 28450157›Full record

ArticleCancer letters2017

The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma.

Hiroaki Miyahara, Sridevi Yadavilli, Manabu Natsumeda, Jeffrey A Rubens, Louis Rodgers, Madhuri Kambhampati, Isabella C Taylor, Harpreet Kaur, Laura Asnaghi, Charles G Eberhart and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 67 citations in OpenAlex.

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  11. Radiotherapy and radio-sensitization in H3CNS neuroscience & therapeutics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Hiroaki MiyaharaDepartment of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sridevi YadavilliResearch Center for Genetic Medicine, Children's National Health System, Washington, District of Columbia 20010, USA.
Manabu NatsumedaDepartment of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jeffrey A RubensDivision of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Louis RodgersNational Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Madhuri KambhampatiResearch Center for Genetic Medicine, Children's National Health System, Washington, District of Columbia 20010, USA.
Isabella C TaylorDivision of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Harpreet KaurDivision of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Laura AsnaghiDepartment of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Charles G EberhartDepartment of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Katherine E WarrenNational Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
Javad NazarianResearch Center for Genetic Medicine, Children's National Health System, Washington, District of Columbia 20010, USA; Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia 20052, USA.
Eric H RaabeDepartment of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: eraabe2@jhmi.edu.
Johns Hopkins University · USChildren's National · USNational Cancer Institute · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Preclinical evaluation of novel therapeutics for CNS tumor therapyZIABC011340 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WARREN, KATHERINE E · 2010 to 2019
$4.1M
Investigating the biology of pediatric gliomasZIABC011514 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WARREN, KATHERINE E · 2013 to 2019
$958k
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

Diffuse intrinsic pontine glioma (DIPG) is an invasive and treatment-refractory pediatric brain tumor. Primary DIPG tumors harbor a number of mutations including alterations in PTEN, AKT, and PI3K and exhibit activation of mammalian Target of Rapamycin Complex 1 and 2 (mTORC1/2). mTORC1/2 regulate protein translation, cell growth, survival, invasion, and metabolism. Pharmacological inhibition of mTORC1 is minimally effective in DIPG. However, the activity of dual TORC kinase inhibitors has not been examined in this tumor type. Nanomolar levels of the mTORC1/2 inhibitor TAK228 reduced expression of p-AKT

Indexed as

ChemoradiotherapyAdenineAnimalsApoptosisBenzoxazolesBrain Stem NeoplasmsCell Line, TumorCell MovementCell ProliferationDose-Response Relationship, DrugGliomaHumansMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Mice, Inbred NODMice, SCIDAdenineBenzoxazolesMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2MTOR protein, humanMultiprotein ComplexesProtein Kinase InhibitorsProto-Oncogene Proteins c-aktPyrimidinesRadiation-Sensitizing AgentsRibosomal Protein S6 KinasessapanisertibTOR Serine-Threonine KinasesINK128MLN0128mTORPediatric brain tumorSapanisertib

Identifiers

PMID28450157
PMCPMC5569904
OpenAlexW2608623782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.