Evidence map›Paper›PMID 28449847›Full record

ArticleCellular immunology2017

Loss of WDFY3 ameliorates severity of serum transfer-induced arthritis independently of autophagy.

Dennis J Wu, Iannis E Adamopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Comprehensive analysis of myeloid reporter mice.bioRxiv : the preprint server for biology · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Dennis J WuGraduate Group in Immunology, University of California at Davis, USA; Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, USA.
Iannis E AdamopoulosGraduate Group in Immunology, University of California at Davis, USA; Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, USA; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Northern California, USA. Electronic address: iannis@ucdavis.edu.
Shriners Hospitals for Children - Northern California · USUniversity of California, Davis · US

Funding

The IL-23/IL-17 Axis in Inflammatory ArthritisR01AR062173 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEVY, DAN · 2012 to 2025
$4.9M
NIAMS NIH HHS R01 AR062173
6 · The paper itself

Abstract

WDFY3 is a master regulator of selective autophagy that we recently showed to interact with TRAF6 and augment RANKL-induced osteoclastogenesis in vitro and in vivo via the NF-κB pathway. Since the NF-κB pathway plays a major role in inflammation herein, we investigate the role of WDFY3 in an arthritis animal model. Our data show that WDFY3 conditional knockout mice (Wdfy3

Indexed as

Adaptor Proteins, Signal TransducingAnimalsArthritis, ExperimentalAutophagosomesAutophagyAutophagy-Related ProteinsCells, CulturedJoint DiseasesMacrophagesMiceMice, Inbred C57BLMice, KnockoutOsteoclastsVesicular Transport ProteinsAdaptor Proteins, Signal TransducingAutophagy-Related ProteinsVesicular Transport ProteinsWdfy3 protein, mouseALFYAutophagyAutophagy-linked FYVE containing proteinMusculoskeletal diseasesOsteoclastWDFY3

Identifiers

PMID28449847
PMCPMC5515728
OpenAlexW2607490811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.