Evidence map›Paper›PMID 28449675›Full record

Observational studyHealth and quality of life outcomes2017

A systematic approach for studying the signs and symptoms of fever in adult patients: the fever assessment tool (FAST).

Nancy J Ames, John H Powers, Alexandra Ranucci, Kyungsook Gartrell, Li Yang, Mark VanRaden, Nancy Kline Leidy, Gwenyth R Wallen

Registry-linked trialAbstract readObservational StudyValidation Study
In one paragraph

Observational study in Health and quality of life outcomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01287143 (Beyond Intuition), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01287143 terminatednot on this map

Beyond Intuition: Quantifying and Understanding the Signs and Symptoms of Fever

TypeobservationalSponsorNational Institutes of Health Clinical Center (CC)Ran2011 to 2017Enrolled99ConditionsFever
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nancy J AmesClinical Center, National Institutes of Health, Bldg 10 Rm 2B-10, 10 Center Drive, Bethesda, MD, 20892, USA. names@nih.gov.
John H PowersClinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, Maryland, 21702, USA.
Alexandra RanucciClinical Center, National Institutes of Health, Bldg 10 Rm 2B-10, 10 Center Drive, Bethesda, MD, 20892, USA.
Kyungsook GartrellNational Library of Medicine/Lister Hill National Center for Biomedical Communications, and National Institutes of Health/Clinical Center Nursing Department, North Bethesda, Maryland, USA.
Li YangClinical Center, National Institutes of Health, Bldg 10 Rm 2B-10, 10 Center Drive, Bethesda, MD, 20892, USA.
Mark VanRadenNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Nancy Kline LeidyEvidera, Bethesda, Maryland, USA.
Gwenyth R WallenClinical Center, National Institutes of Health, Bldg 10 Rm 2B-10, 10 Center Drive, Bethesda, MD, 20892, USA.

Funding

National Biomedical Information ServicesZIHLM200888 · NLM · NATIONAL LIBRARY OF MEDICINE · PI PALTOO, DINA · 2009 to 2025
$5200.7M
BEYOND INTUITION: Quantifying and Understanding the Signs and Symptoms of FeverZIACL001152 · CLC · CLINICAL CENTER · PI AMES, NANCY J. · 2012 to 2017
$0k
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

backgroundAlthough body temperature is one of four key vital signs routinely monitored and treated in clinical practice, relatively little is known about the symptoms associated with febrile states. The purpose of this study was to assess the validity, reliability and feasibility of the Fever Assessment Tool (FAST) in an acute care research setting.

methodsQualitative: To assess content validity and finalize the FAST instrument, 12 adults from an inpatient medical-surgical unit at the National Institutes of Health (NIH) Clinical Center participated in cognitive interviews within approximately 12 h of a febrile state (tympanic temperature ≥ 38° Celsius). Quantitative: To test reliability, validity and feasibility, 56 new adult inpatients completed the 21-item FAST.

resultsThe cognitive interviews clarified and validated the content of the final 21-item FAST. Fifty-six patients completed the FAST from two to 133 times during routine vital sign assessment, yielding 1,699 temperature time points. Thirty-four percent of the patients (N = 19) experienced fever at one or more time points, with a total of 125 febrile time points. Kuder-Richardson 20 (KR-20) reliability of the FAST was 0.70. Four nonspecific symptom categories, Tired or Run-Down (12), Sleepy (13), Weak or Lacking Energy (11), and Thirsty (9) were among the most frequently reported symptoms in all participants. Using Generalized Estimating Equations (GEE), the odds of reporting eight symptoms, Warm (4), Sweating (5), Thirsty (9), General Body Aches (10), Weak or Lacking Energy (11), Tired or Run Down (12) and Difficulty Breathing (17), were increased when patients had a fever (Fever Now), compared to the two other subgroups-patients who had a fever, but not at that particular time point, (Fever Not Now) and patients who never had a fever (Fever Never). Many, but not all, of the comparisons were significant in both groups.

conclusionResults suggest the FAST is reliable, valid and easy to administer. In addition to symptoms usually associated with fever (e.g. feeling warm), symptoms such as Difficulty Breathing (17) were identified with fever. Further study in a larger, more diverse patient population is warranted.

trial registrationClinical Trials Number: NCT01287143 (January 2011).

Indexed as

AdultAgedFemaleFeverHumansMaleMiddle AgedQualitative ResearchQuality of LifeReproducibility of ResultsSurveys and QuestionnairesSymptom AssessmentFever Assessment Tool (FAST)Fever signsFever symptoms

Identifiers

PMID28449675
PMCPMC5408372

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.