Evidence map›Paper›PMID 28449309›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2017

Tumor Targeting with an isoDGR-Drug Conjugate.

Simone Zanella, Simona Angerani, Arianna Pina, Paula López Rivas, Clelia Giannini, Silvia Panzeri, Daniela Arosio, Michele Caruso, Fabio Gasparri, Ivan Fraietta and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Cyclic RGD andMolecules (Basel, Switzerland) · 2020
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Tumor Targeting with an isoDGR-Drug Conjugate.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Simone ZanellaDipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy.ORCID http://orcid.org/0000-0002-8919-6876
Simona AngeraniDipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy.
Arianna PinaDipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy.
Paula López RivasDipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy.
Clelia GianniniDipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy.ORCID http://orcid.org/0000-0003-3376-8350
Silvia PanzeriDipartimento di Scienza e Alta Tecnologia, Università degli Studi dell'Insubria, Via Valleggio 11, 22100, Como, Italy.
Daniela ArosioIstituto di Scienze e Tecnologie Molecolari (ISTM), CNR, Via C. Golgi 19, 20133, Milano, Italy.ORCID http://orcid.org/0000-0001-5486-3504
Michele CarusoNerviano Medical Sciences (NMS), Via Pasteur 10, 20014, Nerviano, Italy.
Fabio GasparriNerviano Medical Sciences (NMS), Via Pasteur 10, 20014, Nerviano, Italy.
Ivan FraiettaNerviano Medical Sciences (NMS), Via Pasteur 10, 20014, Nerviano, Italy.
Clara AlbaneseNerviano Medical Sciences (NMS), Via Pasteur 10, 20014, Nerviano, Italy.
Aurelio MarsiglioNerviano Medical Sciences (NMS), Via Pasteur 10, 20014, Nerviano, Italy.
Luca PignataroDipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy.ORCID http://orcid.org/0000-0002-7200-9720
Laura BelvisiDipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy.ORCID http://orcid.org/0000-0002-3593-2970
Umberto PiarulliDipartimento di Scienza e Alta Tecnologia, Università degli Studi dell'Insubria, Via Valleggio 11, 22100, Como, Italy.ORCID http://orcid.org/0000-0002-6952-1811
Cesare GennariDipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy.ORCID http://orcid.org/0000-0002-7635-4900
University of Milan · ITNerviano Medical Sciences · ITUniversity of Insubria · ITInstitute of Molecular Science and Technologies · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein we report the first example of an isoDGR-drug conjugate (2), designed to release paclitaxel selectively within cancer cells expressing integrin α

Indexed as

Amino Acid SequenceCell Line, TumorCell ProliferationHumansInhibitory Concentration 50Integrin alphaVbeta3OligopeptidesPaclitaxelPeptidomimeticsarginyl-glycyl-aspartic acidIntegrin alphaVbeta3OligopeptidesPaclitaxelPeptidomimeticsantitumor agentscancerdrug deliveryintegrinspeptidomimetics

Identifiers

PMID28449309
PMCPMC5488297
OpenAlexW2608513654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.