ArticleChembiochem : a European journal of chemical biology2017
The Profile and Dynamics of RNA Modifications in Animals.
Article in Chembiochem : a European journal of chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
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- Oligonucleotide Catabolism-Derived Gluconucleosides inJournal of the American Chemical Society · 2023Article
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- Splice site mCell · 2021Article
- Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.The EMBO journal · 2021Article
- Bacterial tRNA 2'-O-methylation is dynamically regulated under stress conditions and modulates innate immune response.Nucleic acids research · 2020Article
- Characterization of UVA-Induced Alterations to Transfer RNA Sequences.Biomolecules · 2020Article
- Probing the diversity and regulation of tRNA modifications.Current opinion in microbiology · 2020Review
- mRNA Editing, Processing and Quality Control inGenetics · 2020Review
- A Systems Chemoproteomic Analysis of Acyl-CoA/Protein Interaction Networks.Cell chemical biology · 2020Article
- Epigenetic regulation by endogenous metabolite pharmacology.Current opinion in chemical biology · 2019Review
- METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.Molecular cell · 2019Article
- Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis.Genes · 2019Article
- The Effects of Ultraviolet Radiation on Nucleoside Modifications in RNA.ACS chemical biology · 2018Article
- Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model OrganismFrontiers in molecular biosciences · 2018Article
- Article
- The Profile and Dynamics of RNA Modifications in Animals.Chembiochem : a European journal of chemical biology · 2017Article
- Function by Structure: Spotlights on Xist Long Non-coding RNA.Frontiers in molecular biosciences · 2017Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
More than a hundred distinct modified nucleosides have been identified in RNA, but little is known about their distribution across different organisms, their dynamic nature and their response to cellular and environmental stress. Mass-spectrometry-based methods have been at the forefront of identifying and quantifying modified nucleosides. However, they often require synthetic reference standards, which do not exist in the case of many modified nucleosides, and this therefore impedes their analysis. Here we use a metabolic labelling approach to achieve rapid generation of bio-isotopologues of the complete Caenorhabditis elegans transcriptome and its modifications and use them as reference standards to characterise the RNA modification profile in this multicellular organism through an untargeted liquid-chromatography tandem high-resolution mass spectrometry (LC-HRMS) approach. We furthermore show that several of these RNA modifications have a dynamic response to environmental stress and that, in particular, changes in the tRNA wobble base modification 5-methoxycarbonylmethyl-2-thiouridine (mcm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.