ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Executive Network Activation is Linked to Walking Speed in Older Adults: Functional MRI and TCD Ultrasound Evidence From the MOBILIZE Boston Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
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- The association between cerebral blood flow and standing dual task performance is dependent upon age group and cognitive load.Scientific reports · 2025Article
- APOE4 carriers resistant to cognitive decline show unique relationships between cerebrovascular response to exercise and dual-task cognitive-balance performance.bioRxiv : the preprint server for biology · 2025Article
- The Science of Tai Chi andJournal of integrative and complementary medicine · 2025Review
- Brain connectivity moderated the effects of cognitive intraindividual variability on mobility in cognitively frail older adults.Frontiers in aging neuroscience · 2025Article
- Sensorimotor and Frontoparietal Network Connectivity Are Associated With Subsequent Maintenance of Gait Speed and Episodic Memory in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Rationale and Design of STAMINA: Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging, A Geroscience Feasibility Study.Translational medicine of aging · 2023Article
- Transcranial Direct Current Stimulation May Reduce Prefrontal Recruitment During Dual Task Walking in Functionally Limited Older Adults - A Pilot Study.Frontiers in aging neuroscience · 2022Article
- Neural correlates of walking post-stroke: neuroimaging insights from the past decade.Experimental brain research · 2021Review
- Executive dysfunction after multiple concussions is not related to cerebrovascular dysfunction.Physiological measurement · 2021Article
- Brain activity during walking in older adults: Implications for compensatory versus dysfunctional accounts.Neurobiology of aging · 2021Review
- Evidence for a Specific Association Between Sustained Attention and Gait Speed in Middle-to-Older-Aged Adults.Frontiers in aging neuroscience · 2021Article
- Ongoing Oscillatory Electrophysiological Alterations in Frail Older Adults: A MEG Study.Frontiers in aging neuroscience · 2021Article
- Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults.Frontiers in aging neuroscience · 2021Article
- Diminished Locomotor Control Is Associated With Reduced Neurovascular Coupling in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Altered Brain Function in Cerebral Small Vessel Disease Patients With Gait Disorders: A Resting-State Functional MRI Study.Frontiers in aging neuroscience · 2020Article
- Functional Connectivity Disruption in Frail Older Adults Without Global Cognitive Deficits.Frontiers in medicine · 2020Article
- Lower Thalamic Blood Flow Is Associated With Slower Stride Velocity in Older Adults.Frontiers in aging neuroscience · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundChanges in cerebral blood flow velocity (CBF) in response to a cognitive task (task-related ΔCBF) have been shown by Transcranial Doppler ultrasonography (TCD) to be reduced in slow walkers. However, it is unknown whether reduced task-related ΔCBF is associated with reduced neural activity in specific brain regions, as measured by blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI).
methodsWe assessed the regional changes in neural activity associated with reduced middle cerebral artery (MCA) task-related ΔCBF to an executive task and slow walking speed in 67 community-dwelling older adults from the MOBILIZE Boston Study. Participants underwent walking assessments and TCD ultrasonography measures of MCA ΔCBF during the n-back task of executive function. A subset of participants (n = 27) completed the same task during fMRI. Individual BOLD activation maps for the n-back task were correlated with TCD measures and network-level averages were associated with TCD and preferred walking speed.
resultsParticipants with diminished task-related ΔCBF walked more slowly (β = .39, p = .001). fMRI revealed significant associations between task-related ΔCBF and regional BOLD activation in several brain regions/networks supplied by the MCA. Of these regions and networks, those within the executive network were most strongly associated with walking speed (β = .36, p = .01).
conclusionsTask-related ΔCBF during an executive function task is related to activation in several neural networks and impairment in the ability to recruit the executive network in particular is associated with slow walking speed in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.