ArticleEnvironmental research2017
Associations between blood BTEXS concentrations and hematologic parameters among adult residents of the U.S. Gulf States.
Article in Environmental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 59 citations in OpenAlex.
- Detection and Proinflammatory Effects of BTEX within the Human Atherosclerotic Plaque.Environmental science & technology · 2025Observational
- Blood concentrations of volatile organic compounds and hypertension in the GuLF Study.The Science of the total environment · 2025Article
- Hematological biochemical and liver function changes associated with BTEX exposure in a six year retrospective cohort study.Scientific reports · 2025Article
- Association between occupational exposure to gasoline and anemia: a retrospective cohort study in China.BMC public health · 2025Article
- Environmental chemical-wide associations with immune biomarkers in US adults: A cross-sectional analysis.Environmental research · 2024Article
- Article
- Biological effects of inhaled crude oil vapor V. Altered biogenic amine neurotransmitters and neural protein expression.Toxicology and applied pharmacology · 2022Article
- Assessing volatile organic compounds exposure and prostate-specific antigen: National Health and Nutrition Examination Survey, 2001-2010.Frontiers in public health · 2022Article
- E-Waste in Africa: A Serious Threat to the Health of Children.International journal of environmental research and public health · 2021Review
- Associations between select blood VOCs and hematological measures in NHANES 2005-2010.Journal of exposure science & environmental epidemiology · 2021Article
- Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study.BMC public health · 2020Article
- Blood BTEX levels and neurologic symptoms in Gulf states residents.Environmental research · 2019Article
- The hematologic effects of BTEX exposure among elderly residents in Nanjing: a cross-sectional study.Environmental science and pollution research international · 2019Article
- The Development of Long-Term Adverse Health Effects in Oil Spill Cleanup Workers of the Deepwater Horizon Offshore Drilling Rig Disaster.Frontiers in public health · 2018Article
- Toluene exposure and changes in platelet count: a narrative review.Revista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMTReview
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundStudies of workers exposed to benzene at average air concentrations below one part per million suggest that benzene, a known hematotoxin, causes hematopoietic damage even at low exposure levels. However, evidence of such effects outside of occupational settings and for other volatile organic compounds (VOCs) is limited.
objectiveTo investigate associations between ambient exposures to five VOCs, including benzene, and hematologic parameters among adult residents of the U.S. Gulf Coast. MATERIALS AND
methodsBlood concentrations of selected VOCs were measured in a sample of adult participants in the Gulf Long-term Follow-up Study (GuLF STUDY) during 2012 and 2013. Complete blood counts with differentials were also performed on a subset of participants (n=406). We used these data together with detailed questionnaire data to estimate adjusted associations between blood BTEXS (benzene, toluene, ethylbenzene, o-xylene, m/p-xylene, and styrene) concentrations and hematologic parameters using generalized linear models.
resultsWe observed inverse associations between blood benzene concentrations and hemoglobin concentration and mean corpuscular hemoglobin concentration, and a positive association with red cell distribution width among tobacco smoke-unexposed participants (n=146). Among tobacco smoke-exposed participants (n=247), we observed positive associations between blood VOC concentrations and several hematologic parameters, including increased white blood cell and platelet counts, suggestive of hematopoietic stimulation typically associated with tobacco smoke exposure. Most associations were stronger for benzene than for the other VOCs.
conclusionsOur results suggest that ambient exposure to BTEXS, particularly benzene, may be associated with hematologic effects, including decreased hemoglobin concentration, mean corpuscular hemoglobin concentration, and increased red cell distribution width.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.