ArticleRNA biology2017
Circular RNAs with hammerhead ribozymes encoded in eukaryotic genomes: The enemy at home.
Article in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Diversity and evolution of viroids and viroid-like agents with circular RNA genomes revealed by metatranscriptome mining.Nucleic acids research · 2025Article
- Viroids and Retrozymes: Plant Circular RNAs Capable of Autonomous Replication.Plants (Basel, Switzerland) · 2024Review
- Understanding viroids, endogenous circular RNAs, and viroid-like RNAs in the context of biogenesis.PLoS pathogens · 2024Article
- Uncovered diversity of infectious circular RNAs: A new paradigm for the minimal parasites?Npj viruses · 2024Review
- Viroids, Satellite RNAs and Prions: Folding of Nucleic Acids and Misfolding of Proteins.Viruses · 2024Article
- Cellular roadmaps of viroid infection.Trends in microbiology · 2023Review
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- In-Plant Persistence and Systemic Transport ofInternational journal of molecular sciences · 2022Article
- Viroids and Viroid-like Circular RNAs: Do They Descend from Primordial Replicators?Life (Basel, Switzerland) · 2022Article
- ViroidDB: a database of viroids and viroid-like circular RNAs.Nucleic acids research · 2022Article
- A scenario for the emergence of protoviroids in the RNA world and for their further evolution into viroids and viroid-like RNAs by modular recombinations and mutations.Virus evolution · 2022Review
- Genome Evolution from Random Ligation of RNAs of Autocatalytic Sets.International journal of molecular sciences · 2021Article
- Hepatitis Delta Virus (HDV) and Delta-Like Agents: Insights Into Their Origin.Frontiers in microbiology · 2021Review
- Hepatitis delta virus-like circular RNAs from diverse metazoans encode conserved hammerhead ribozymes.Virus evolution · 2021Article
- A Singular and Widespread Group of Mobile Genetic Elements: RNA Circles with Autocatalytic Ribozymes.Cells · 2020Review
- Small circRNAs with self-cleaving ribozymes are highly expressed in diverse metazoan transcriptomes.Nucleic acids research · 2020Article
- Bulky cations greatly increase the turnover of a native hammerhead ribozyme.RSC advances · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new family of non-autonomous retrotransposons with self-cleaving hammerhead ribozymes, the so called retrozymes, has recently been found encoded in diverse plant genomes. These retroelements can be actively transcribed, and their RNAs accumulate in the cells as abundant non-coding circular RNAs (circRNAs) of small size (600-1000 nt). Related circRNAs with self-cleaving ribozymes had already been described in plants, and belong to a group of infectious RNA agents with an uncertain origin: the viroids and viroid-like satellites of plant RNA viruses. These pathogenic circRNAs show many structural similarities with retrozyme circRNAs, and both have been found to occur in flowering plants as heterogeneous RNA molecules of positive and negative polarities. Taking all these data together, we hypothesize that circRNAs encoded by genomic retrozymes could have given origin to infectious circRNAs with self-cleaving ribozymes. Moreover, we propose that retrozymes in time could have evolved from the ancient family of Penelope-like retroelements, which also harbour hammerhead ribozymes. Putative retrozyme sequences with hammerhead ribozymes have been detected as well in metazoan genomes, opening the door to a common occurrence of circRNAs with self-cleaving motifs among eukaryotes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.