ArticlePloS one2017
Dynamics and complexity of body temperature in preterm infants nursed in incubators.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Cycled light in the intensive care unit for preterm and low birth weight infants.The Cochrane database of systematic reviews · 2024Pooled it
- Sample entropy of oxygen saturation in preterm infants.Scientific reports · 2025Article
- Preclinical validation of NeoWarm, a low-cost infant warmer and carrier device, to ameliorate induced hypothermia in newborn piglets as models for human neonates.Frontiers in pediatrics · 2024Article
- A Setup for Camera-Based Detection of Simulated Pathological States Using a Neonatal Phantom.Sensors (Basel, Switzerland) · 2022Article
- Precision caffeine therapy for apnea of prematurity and circadian rhythms: New possibilities open up.Frontiers in pharmacology · 2022Review
- The rhythm of a preterm neonate's life: ultradian oscillations of heart rate, body temperature and sleep cycles.Journal of pharmacokinetics and pharmacodynamics · 2021Observational
- Body temperature instability and respiratory morbidity in the very low birth weight infant: a multiple case, intensive longitudinal study.BMC pediatrics · 2020Article
- Fever Time Series Analysis Using Slope Entropy. Application to Early Unobtrusive Differential Diagnosis.Entropy (Basel, Switzerland) · 2020Article
- Caffeine preserves quiet sleep in preterm neonates.Pharmacology research & perspectives · 2020Observational
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoor control of body temperature is associated with mortality and major morbidity in preterm infants. We aimed to quantify its dynamics and complexity to evaluate whether indices from fluctuation analyses of temperature time series obtained within the first five days of life are associated with gestational age (GA) and body size at birth, and presence and severity of typical comorbidities of preterm birth.
methodsWe recorded 3h-time series of body temperature using a skin electrode in incubator-nursed preterm infants. We calculated mean and coefficient of variation of body temperature, scaling exponent alpha (Talpha) derived from detrended fluctuation analysis, and sample entropy (TSampEn) of temperature fluctuations. Data were analysed by multilevel multivariable linear regression.
resultsData of satisfactory technical quality were obtained from 285/357 measurements (80%) in 73/90 infants (81%) with a mean (range) GA of 30.1 (24.0-34.0) weeks. We found a positive association of Talpha with increasing levels of respiratory support after adjusting for GA and birth weight z-score (p<0.001; R2 = 0.38).
conclusionDynamics and complexity of body temperature in incubator-nursed preterm infants show considerable associations with GA and respiratory morbidity. Talpha may be a useful marker of autonomic maturity and severity of disease in preterm infants.
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