ArticlePloS one2017
Circulating leptin and adiponectin are associated with insulin resistance in healthy postmenopausal women with hot flashes.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Obesity and female reproductive health in Asian population.Obesity pillars · 2026Review
- Adverse Cardiometabolic Impacts of Sleep Fragmentation and Estradiol Suppression: An Experimental Model of Menopause.The Journal of clinical endocrinology and metabolism · 2026Article
- Effects of menopause on temperature regulation.Temperature (Austin, Tex.) · 2025Review
- Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan.Frontiers in endocrinology · 2025Review
- Effects of voluntary wheel running on appetite-regulating peptides and neuroinflammation in the hypothalamus of ovariectomized middle-aged mice.Frontiers in molecular neuroscience · 2025Article
- Cohort Profile Update: Project Viva mothers.International journal of epidemiology · 2023Article
- Vasomotor symptoms and their links to cardiovascular disease risk.Current opinion in endocrine and metabolic research · 2023Article
- Prophylactic effect ofJournal of traditional and complementary medicine · 2022Article
- The relationship between hot flashes and fatty acid binding protein 2 in postmenopausal women.PloS one · 2022Article
- Relationships between depression and anxiety symptoms and adipocyte-derived proteins in postmenopausal women.PloS one · 2021Article
- Observational
- Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women.Metabolites · 2020Article
- Perimenopause, body fat, metabolism and menopausal symptoms in relation to serum markers of adiposity, inflammation and digestive metabolism.Journal of endocrinological investigation · 2020Article
- Effects of resistance exercise on adipokine factors and body composition in pre- and postmenopausal women.Journal of exercise rehabilitation · 2019Article
- Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women.PloS one · 2019Article
- Article
- Circulating interleukin-8 and tumor necrosis factor-α are associated with hot flashes in healthy postmenopausal women.PloS one · 2017Article
- Expanded Normal Weight Obesity and Insulin Resistance in US Adults of the National Health and Nutrition Examination Survey.Journal of diabetes research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHot flashes have been postulated to be linked to the development of metabolic disorders. This study aimed to evaluate the relationship between hot flashes, adipocyte-derived hormones, and insulin resistance in healthy, non-obese postmenopausal women. PARTICIPANTS AND
designIn this cross-sectional study, a total of 151 women aged 45-60 years were stratified into one of three groups according to hot-flash status over the past three months: never experienced hot flashes (Group N), mild-to-moderate hot flashes (Group M), and severe hot flashes (Group S). Variables measured in this study included clinical parameters, hot flash experience, fasting levels of circulating glucose, lipid profiles, plasma insulin, and adipocyte-derived hormones. Multiple linear regression analysis was used to evaluate the associations of hot flashes with adipocyte-derived hormones, and with insulin resistance. SETTINGS: The study was performed in a hospital medical center.
resultsThe mean (standard deviation) of body-mass index was 22.8(2.7) for Group N, 22.6(2.6) for Group M, and 23.5(2.4) for Group S, respectively. Women in Group S displayed statistically significantly higher levels of leptin, fasting glucose, and insulin, and lower levels of adiponectin than those in Groups M and N. Multivariate linear regression analysis revealed that hot-flash severity was significantly associated with higher leptin levels, lower adiponectin levels, and higher leptin-to-adiponectin ratio. Univariate linear regression analysis revealed that hot-flash severity was strongly associated with a higher HOMA-IR index (% difference, 58.03%; 95% confidence interval, 31.00-90.64; p < 0.001). The association between hot flashes and HOMA-IR index was attenuated after adjusting for leptin or adiponectin and was no longer significant after simultaneously adjusting for leptin and adiponectin.
conclusionThe present study provides evidence that hot flashes are associated with insulin resistance in postmenopausal women. It further suggests that hot flash association with insulin resistance is dependent on the combination of leptin and adiponectin variables.
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