ArticlePloS one2017
A longitudinal cline characterizes the genetic structure of human populations in the Tibetan plateau.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Genetic structure and admixture of the Yi and Qiang in southwestern China.Journal of Zhejiang University. Science. B · 2026Article
- Population genomics advances in frontier ethnic minorities in China.Science China. Life sciences · 2025Review
- Higher oxygen content and transport characterize high-altitude ethnic Tibetan women with the highest lifetime reproductive success.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Human genetic history on the Tibetan Plateau in the past 5100 years.Science advances · 2023Article
- Ancient genomes from the Himalayas illuminate the genetic history of Tibetans and their Tibeto-Burman speaking neighbors.Nature communications · 2022Article
- Tracing the Genetic Legacy of the Tibetan Empire in the Balti.Molecular biology and evolution · 2021Article
- Ancient genomes from northern China suggest links between subsistence changes and human migration.Nature communications · 2020Article
- Genetic Landscapes Reveal How Human Genetic Diversity Aligns with Geography.Molecular biology and evolution · 2020Article
- Spatially explicit analysis reveals complex human genetic gradients in the Iberian Peninsula.Scientific reports · 2019Article
- Evidence of Polygenic Adaptation to High Altitude from Tibetan and Sherpa Genomes.Genome biology and evolution · 2018Article
- Selecting among Alternative Scenarios of Human Evolution by Simulated Genetic Gradients.Genes · 2018Review
- Demographic History and Genetic Adaptation in the Himalayan Region Inferred from Genome-Wide SNP Genotypes of 49 Populations.Molecular biology and evolution · 2018Article
- The genomic landscape of Nepalese Tibeto-Burmans reveals new insights into the recent peopling of Southern Himalayas.Scientific reports · 2017Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Indigenous populations of the Tibetan plateau have attracted much attention for their good performance at extreme high altitude. Most genetic studies of Tibetan adaptations have used genetic variation data at the genome scale, while genetic inferences about their demography and population structure are largely based on uniparental markers. To provide genome-wide information on population structure, we analyzed new and published data of 338 individuals from indigenous populations across the plateau in conjunction with worldwide genetic variation data. We found a clear signal of genetic stratification across the east-west axis within Tibetan samples. Samples from more eastern locations tend to have higher genetic affinity with lowland East Asians, which can be explained by more gene flow from lowland East Asia onto the plateau. Our findings corroborate a previous report of admixture signals in Tibetans, which were based on a subset of the samples analyzed here, but add evidence for isolation by distance in a broader geospatial context.
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