Evidence map›Paper›PMID 28448500›Full record

SynthesisPLoS genetics2017

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

Mariaelisa Graff, Robert A Scott, Anne E Justice, Kristin L Young, Mary F Feitosa, Llilda Barata, Thomas W Winkler, Audrey Y Chu, Anubha Mahajan, David Hadley and 274 more

Erratum issued Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03766191 (The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children), which is not on this map. Cited by 115 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03766191 nacompletednot on this mapstarted 2019, after this paper: background citation

The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children

TypeinterventionalSponsorTrustees of Dartmouth CollegeRan2019 to 2024Enrolled189ConditionsChildhood ObesityArmsFood Ads, Non-food Ads
3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 13 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Pooled it
  14. Trial
  15. Trial
  16. Review
  17. HiFiMAP: High-resolution fast identity-by-descent mapping test.medRxiv : the preprint server for health sciences · 2026
    Article
  18. Article
  19. Review
  20. Article

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

284 authors.

Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.ORCID http://orcid.org/0000-0001-6380-1735
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Anne E JusticeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Kristin L YoungDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.ORCID http://orcid.org/0000-0003-0070-6145
Mary F FeitosaDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Llilda BarataDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.ORCID http://orcid.org/0000-0003-0292-5421
Audrey Y ChuNational Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
David HadleyDivision of Population Health Sciences and Education, St. George's, University of London, London, United Kingdom.
Luting XueNational Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
Tsegaselassie WorkalemahuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Nancy L Heard-CostaNational Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.ORCID http://orcid.org/0000-0001-9730-0306
Marcel den HoedMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Tarunveer S AhluwaliaNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Julius S NgwaHoward University, Department of Internal Medicine, Washington DC, United States of America.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0001-6053-298X
Lydia QuayeDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
John D EicherPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, United States of America.
James E HayesCell and Developmental Biology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York, United States of America.
Marilyn CornelisDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Zoltan KutalikInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Elise LimDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Jian'an LuanMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Jennifer E HuffmanNational Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
Weihua ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Paula J GriffinDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Toomas HallerEstonian Genome Center, University of Tartu, Tartu, Estonia.
Shafqat AhmadDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Pedro M Marques-VidalDepartment of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Stephanie BienDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Loic YengoUniversity of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Albert Vernon SmithIcelandic Heart Association, Kopavogur, Iceland.
Meena KumariISER, University of Essex, Colchester, Essex, United Kingdom.
Marie Neergaard HarderNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Johanne Marie JustesenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Mette HollenstedNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kurt LohmanDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Natalia V RiveraKarolinska Institutet, Respiratory Unit, Department of Medicine Solna, Stockholm, Sweden.
John B WhitfieldGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jing Hua ZhaoMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Heather M StringhamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Charlotte HuppertzDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Wouter J PeyrotDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Kati KristianssonNational Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Ayse DemirkanGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Myriam FornageInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Maija HassinenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Gemma CadbyCentre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia, Australia.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Anne U JacksonCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Jennifer L Bragg-GreshamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Jonathan MartenMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Pau NavarroMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Claire BellisHuman Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore.
Dorota PaskoGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.
Åsa JohanssonDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Søren SnitkerDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Yu-Ching ChengDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Joel ErikssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Unhee LimEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.
Mette AadahlResearch Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
Linda S AdairDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Beverley BalkauINSERM U-1018, CESP, Renal and Cardiovascular Epidemiology, UVSQ-UPS, Villejuif, France.
Juha AuvinenCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
John BeilbyBusselton Population Medical Research Institute, Nedlands, Western Australia, Australia.
Richard N BergmanDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Sven BergmannSwiss Institute of Bioinformatics, Lausanne, Switzerland.
Alain G BertoniDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
John BlangeroTexas Biomedical Research Institute, San Antonio, Texas, United States of America.
Amélie BonnefondUniversity of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
Lori L BonnycastleMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Judith B BorjaUSC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.
Søren BrageMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Fabio BusoneroIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Steve BuyskeDepartment of Genetics, Rutgers University, Piscataway, New Jersey, United States of America.
Harry CampbellCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, Edinburgh, Scotland.
Peter S ChinesMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Tanguy CorreSwiss Institute of Bioinformatics, Lausanne, Switzerland.
George Davey SmithMRC Integrative Epidemiology Unit & School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Nicole DuekerUniversity of Maryland School of Medicine, Department of Epidemiology & Public Health, Baltimore, Maryland, United States of America.
Marcus DörrDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Tapani EbelingDepartment of Medicine, Oulu University Hospital, Oulu, Finland.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America.
Mao FuDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Kristine FærchSteno Diabetes Center, Gentofte, Denmark.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Sven GläserDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Jian GongDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Penny Gordon-LarsenCarolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Tanja B GrammerVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gerard van GrootheestDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
Kennet HaraldNational Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Nicholas D HastieMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Aki S HavulinnaNational Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Dena HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America.
Lucia HindorffDivision of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Lynne J HockingMusculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom.
Oddgeir L HolmensSt. Olav Hospital, Trondheim University Hospital, Trondheim, Norway.
Christina HolzapfelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Jouke Jan HottengaDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Jie HuangDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
Tao HuangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Jennie HuiBusselton Population Medical Research Institute, Nedlands, Western Australia, Australia.
Cornelia HuthInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Nina Hutri-KähönenDepartment of Pediatrics, Tampere University Hospital, Tampere, Finland.
Alan L JamesBusselton Population Medical Research Institute, Nedlands, Western Australia, Australia.
John-Olov JanssonDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Min A JhunDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Markus JuonalaDepartment of Medicine, University of Turku, Turku, Finland.
Leena KinnunenNational Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Heikki A KoistinenNational Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Ivana KolcicDepartment of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Pirjo KomulainenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Johanna KuusistoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Kirsti KvaløyHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Timo A LakkaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Lenore J LaunerNeuroepidemiology Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Benjamin LehneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Mattias LorentzonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Robert LubenDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Michel MarreINSERM U-1138, Équipe 2: Pathophysiology and Therapeutics of Vascular and Renal diseases Related to Diabetes, Centre de Recherche des Cordeliers, Paris, France.
Yuri MilaneschiDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
Keri L MondaDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Grant W MontgomeryGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Marleen H M De MoorEMGO+ Institute, Vrije Universiteit & VU University Medical Center, Amsterdam, The Netherlands.
Antonella MulasIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
A W MuskBusselton Population Medical Research Institute, Nedlands, Western Australia, Australia.
Reija MännikköKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Satu MännistöNational Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Narisu NarisuMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Matthias NauckDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Jennifer A NettletonDivision of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Matthias OldenDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Ken K OngMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Sandosh PadmanabhanGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Lavinia PaternosterMRC Integrative Epidemiology Unit & School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Jeremiah PerezDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Markus PerolaNational Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Inga ProkopenkoGenomics of Common Disease, Imperial College London, London, United Kingdom.
Hannu PuolijokiSouth Ostrobothnia Central Hospital, Seinäjoki, Finland.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Laura J Rasmussen-TorvikDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Rajesh RawalResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Igor RudanCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, Edinburgh, Scotland.
Cinzia SartiSocial Services and Health Care Department, City of Helsinki, Helsinki, Finland.
Mark A SarzynskiHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Kai SavonenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
William R ScottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Serena SannaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Alan R ShuldinerDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Steve SidneyDivision of Research, Kaiser Permanente Northern California, Oakland, California, United States of America.
Günther SilbernagelDivision of Angiology, Department of Internal Medicine, Medical University Graz, Austria.
Blair H SmithGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Alena StančákováDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Barbara SternfeldDivision of Research, Kaiser Permanente Northern California, Oakland, California, United States of America.
Amy J SwiftMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Tuija TammelinLIKES Research Center for Sport and Health Sciences, Jyväskylä, Finland.
Sian-Tsung TanNational Heart and Lung Institute, Imperial College London, United Kingdom.
Barbara ThorandInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Dorothée ThuillierUniversity of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
Liesbeth VandenputCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Henrik VestergaardNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jana V van Vliet-OstaptchoukDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Marie-Claude VohlInstitute of Nutrition and Functional Foods, Quebec, Canada.
Uwe VölkerDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Gérard WaeberDepartment of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Mark WalkerInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Sarah WildCentre for Population Health Sciences, Usher Institute for Population Health Sciences and Informatics, Teviot Place, Edinburgh, Scotland.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
Alan F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
M Carola ZillikensDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Niha ZubairDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Christopher A HaimanDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Loic LemarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.
Ulf GyllenstenDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Albert HofmanDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
André G UitterlindenDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Louis PérusseInstitute of Nutrition and Functional Foods, Quebec, Canada.
James F WilsonMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Ozren PolasekCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, Edinburgh, Scotland.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Kristian HveemHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Anke TönjesUniversity of Leipzig, Medical Department, Leipzig, Germany.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze, Florence, Italy.
Lyle J PalmerSchool of Public Health, University of Adelaide, Adelaide, South Australia, Australia.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jaakko TuomilehtoNational Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Veikko SalomaaNational Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Brenda W J H PenninxDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
Eco J C de GeusDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Diana KuhMRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Allan LinnebergResearch Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Mika KivimäkiDepartment of Epidemiology and Public Health, University College London, London, United Kingdom.
Tamara B HarrisLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, Maryland, United States of America.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Lu QiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Marjo-Riitta JärvelinDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
John C ChambersDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital HNS Trust, Middlesex, United Kingdom.
Philippe FroguelUniversity of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Peter VollenweiderDepartment of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Göran HallmansDepartment of Biobank Research, Umeå University, Umeå, Sweden.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America.
David J PorteousGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Eric BoerwinkleDivision of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
CHARGE Consortium
EPIC-InterAct Consortium
PAGE Consortium
Gonçalo R AbecasisCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Inês BarrosoWellcome Trust Sanger Institute, Hinxton, United Kingdom.ORCID http://orcid.org/0000-0001-5800-4520
Mark I McCarthyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Michael BoehnkeCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Iris M HeidDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
David P StrachanPopulation Health Research Institute, St. George's University of London, London, United Kingdom.ORCID http://orcid.org/0000-0001-7854-1366
Caroline S FoxPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, United States of America.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.ORCID http://orcid.org/0000-0002-0703-0742
Joel N HirschhornDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
Robert J KleinIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.ORCID http://orcid.org/0000-0003-3539-5391
Andrew D JohnsonNational Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
Ingrid B BoreckiDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Paul W FranksDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Kari E NorthCarolina Center for Genome Sciences, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
L Adrienne CupplesNational Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
Ruth J F LoosMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Tuomas O KilpeläinenMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
BLRD VA IK2 BX001823British Heart Foundation RG/10/12/28456Intramural NIH HHS Z01 HG000024Medical Research Council G0600705Medical Research Council G0601966Medical Research Council G0700931Medical Research Council G0701863Medical Research Council G1002319Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_U106179473Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/3Medical Research Council MC_UU_12019/1Medical Research Council MR/K002414/1Medical Research Council MR/K013351/1NCATS NIH HHS KL2 TR001109NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCI NIH HHS P01 CA033619NCI NIH HHS R01 CA047988NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA136792NCI NIH HHS UM1 CA182913NCRR NIH HHS UL1 RR025005NEI NIH HHS T32 EY022303NHGRI NIH HHS N01 HG065403NHGRI NIH HHS R01 HG002651NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004790NHGRI NIH HHS U01 HG004802NHGRI NIH HHS U01 HG007033NHGRI NIH HHS U01 HG007376NHLBI NIH HHS K99 HL130580NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055022NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL036310NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL088451NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R21 HL126024NHLBI NIH HHS RC1 HL100245NHLBI NIH HHS T32 HL007055NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL084729NHLBI NIH HHS U01 HL084756NHLBI NIH HHS U10 HL054457NHLBI NIH HHS U10 HL054481NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA013326NIAAA NIH HHS R01 AA014041NIA NIH HHS N01 AG012100NIA NIH HHS N01 AG012109NIA NIH HHS R01 AG013196NIA NIH HHS R03 AG046389NIA NIH HHS R37 AG013196NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG009740NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD057194NICHD NIH HHS R21 HD095164NICHD NIH HHS R24 HD050924NIDA NIH HHS R01 DA012854NIDA NIH HHS R56 DA012854NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK091718NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R01 DK100383NIDDK NIH HHS U01 DK078616NIDDK NIH HHS UM1 DK078616NIEHS NIH HHS P30 ES010126NIH HHS S10 OD018522NIH HHS S10 OD020069NIMHD NIH HHS R01 MD009164NIMH NIH HHS R01 MH063706NIMH NIH HHS R01 MH066206NIMH NIH HHS R01 MH081802NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U01 MH085520NIMH NIH HHS U24 MH068457Wellcome TrustWHI NIH HHS N01 WH022110
6 · The paper itself

Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

Indexed as

ExerciseAdiposityAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexEpigenomicsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleObesityWaist CircumferenceWaist-Hip RatioAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, human

Identifiers

PMID28448500
PMCPMC5407576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.