ReviewBiology2017
Is Polysialylated NCAM Not Only a Regulator during Brain Development But also during the Formation of Other Organs?
Review in Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Using Polysialylated Streptavidin as an Analytical Tool to Visualize Interaction Partners of Polysialic Acid.Molecules (Basel, Switzerland) · 2026Article
- Polysialic Acid Synthesis on theACS omega · 2026Article
- Cadmium impairs heart ventricular formation and disrupts polysialylated-NCAM/FGF receptor signaling in Xenopus tadpoles.Cell & bioscience · 2026Article
- Salmonid polysialyltransferases to generate a variety of sialic acid polymers.Scientific reports · 2023Article
- Knockout of the polysialyltransferases ST8SiaII and ST8SiaIV leads to a dilatation of rete testis during postnatal development.Frontiers in physiology · 2023Article
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- Human adenovirus binding to host cell receptors: a structural view.Medical microbiology and immunology · 2020Review
- The Bovine Antimicrobial Peptide Lactoferricin Interacts with Polysialic Acid without Loss of Its Antimicrobial Activity againstAnimals : an open access journal from MDPI · 2019Article
- Polysialic Acid Modulates the Binding of External Lactoferrin in Neutrophil Extracellular Traps.Biology · 2019Article
- Glycans as Modulators for the Formation and Functional Properties of Neutrophil Extracellular Traps: Used by the Forces of Good and Evil.Frontiers in immunology · 2019Review
- Designer Oncolytic Adenovirus: Coming of Age.Cancers · 2018Review
- Polysialic Acid in Human Plasma Can Compensate the Cytotoxicity of Histones.International journal of molecular sciences · 2018Article
- Polysialic acid is a cellular receptor for human adenovirus 52.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Autopolysialylation of polysialyltransferases is required for polysialylation and polysialic acid chain elongation on select glycoprotein substrates.The Journal of biological chemistry · 2018Article
- Polysialic acid is released by human umbilical vein endothelial cells (HUVEC) in vitro.Cell & bioscience · 2018Article
- Individual Impact of Distinct Polysialic Acid Chain Lengths on the Cytotoxicity of Histone H1, H2A, H2B, H3 and H4.Polymers · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals several cell adhesion molecules are involved during the pre- and postnatal development of all organ systems. A very prominent member of this family is the neural cell adhesion molecule (NCAM). Interestingly, NCAM can be a target for a special form of posttranslational modification: polysialylation. Whereas nearly all extracellular proteins bear mono-sialic acid residues, only a very small group can be polysialylated. Polysialic acid is a highly negatively-charged sugar polymer and can comprise more than 90 sialic acid residues in postnatal mouse brains increasing dramatically the hydrodynamic radius of their carriers. Thus, adhesion and communication processes on cell surfaces are strongly influenced allowing, e.g., the migration of neuronal progenitor cells. In the developing brain the essential role of polysialylated NCAM has been demonstrated in many studies. In comparison to the neuronal system, however, during the formation of other organs the impact of the polysialylated form of NCAM is not well characterized and the number of studies is limited so far. This review summarizes these observations and discusses possible roles of polysialylated NCAM during the development of organs other than the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.