Evidence map›Paper›PMID 28448144›Full record

ArticleJournal of natural products2017

A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens.

Robin B Kinnel, Eduardo Esquenazi, Tiago Leao, Nathan Moss, Emily Mevers, Alban R Pereira, Emily A Monroe, Anton Korobeynikov, Thomas F Murray, David Sherman and 3 more

Abstract read
In one paragraph

Article in Journal of natural products, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Metabolomics Applied to Cyanobacterial Toxins and Natural Products.Advances in experimental medicine and biology · 2023
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Discovery of Cyanobacterial Natural Products Containing Fatty Acid Residues*.Angewandte Chemie (International ed. in English) · 2021
    Article
  14. Article
  15. ACS chemical biology · 2020
    Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Robin B KinnelDepartment of Chemistry, Hamilton College , Clinton, New York 13323, United States.
Eduardo Esquenazi
Tiago Leao
Nathan Moss
Emily Mevers
Alban R Pereira
Emily A MonroeDepartment of Biology, William Paterson University of New Jersey , Wayne, New Jersey 07470, United States.
Anton KorobeynikovFaculty of Mathematics and Mechanics and Center for Algorithmic Biotechnology, Saint Petersburg State University , Saint Petersburg 199034, Russia.
Thomas F MurraySchool of Medicine, Department of Pharmacology, Creighton University , Omaha, Nebraska 68178, United States.
David ShermanLife Sciences Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.
Lena Gerwick
Pieter C Dorrestein
William H GerwickORCID 0000-0003-1403-4458

Funding

Unified Computation Tools for Natural Products ResearchR01GM107550 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COTTRELL, GARRISON W, GERWICK, WILLIAM HENRY · 2013 to 2025
$8.2M
Neurotoxins from Marine Algae and CyanobacteriaR01NS053398 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GERWICK, WILLIAM HENRY, MURRAY, THOMAS F · 2005 to 2015
$4.3M
Discovery of Anticancer Drugs from CyanophytesR01CA100851 · NCI · HENRY FORD HEALTH SYSTEM · PI VALERIOTE, FREDERICK AUGUSTUS · 2004 to 2013
$3.8M
Training Program in Marine BiotechnologyT32GM067550 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GERWICK, WILLIAM HENRY · 2004 to 2019
$2.0M
Development of an efficient cyanobacterial platform for heterologous expression and biosynthetic interrogations of natural products.R01GM118815 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GERWICK, LENA, GERWICK, WILLIAM HENRY · 2017 to 2020
$1.2M
NCI NIH HHS R01 CA100851NIGMS NIH HHS R01 GM107550NIGMS NIH HHS R01 GM118815NIGMS NIH HHS T32 GM067550NINDS NIH HHS R01 NS053398
6 · The paper itself

Abstract

Genome sequencing of microorganisms has revealed a greatly increased capacity for natural products biosynthesis than was previously recognized from compound isolation efforts alone. Hence, new methods are needed for the discovery and description of this hidden secondary metabolite potential. Here we show that provision of heavy nitrogen

Indexed as

Biological ProductsComputational BiologyCyanobacteriaMagnetic Resonance SpectroscopyMolecular StructureOligopeptidesBiological ProductscryptomaldamideOligopeptides

Identifiers

PMID28448144
PMCPMC5748289

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.