ArticleThe journal of nutrition, health & aging2017
DNA Damage, Copper and Lead Associates with Cognitive Function among Older Adults.
Article in The journal of nutrition, health & aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Systematic Review and Meta-Analysis on Heavy Metals and Trace Elements in Mild Cognitive Impairment.Biological trace element research · 2026Pooled it
- Peripheral and central auditory impairment linked to heavy metal exposure in Nicaraguan children from artisanal mining communities.Journal of global health · 2026Article
- Lead exposure and physical frailty in patients with type 2 diabetes mellitus: cross-sectional results from the METAL study.Endocrine · 2025Article
- The interaction effect of metals exposure and dietary habit on cognitive function in Chinese older adult cohort.The journal of nutrition, health & aging · 2024Article
- Association between Multiple Trace Elements, Executive Function, and Cognitive Impairment with No Dementia in Older Adults.Nutrients · 2024Article
- Associations Between Plasma Metals and Cognitive Function in People Aged 60 and Above.Biological trace element research · 2022Article
- Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study.International journal of environmental research and public health · 2022Article
- General Aspects of Metal Ions as Signaling Agents in Health and Disease.Biomolecules · 2020Review
- Article
- Toenail Metal Exposures in Fishermen from Bodo City, Nigeria.Bulletin of environmental contamination and toxicology · 2020Article
- Toenails as biomarker of exposure to essential trace metals: A review.Environmental research · 2019Review
- Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study.Clinical interventions in aging · 2019Article
- Antioxidant Potential, DNA Damage, Inflammation, Glycemic Control and Lipid Metabolism Alteration: A Mediation Analysis of Islamic Sunnah Intermittent Fasting on Cognitive Function among Older Adults with Mild Cognitive Impairment.The journal of nutrition, health & agingArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA cross sectional study was conducted in a group of 317 subjects older than 60 in Malaysia, aimed to determine risk factors associated with cognitive impairment in older adults, focusing on trace elements and DNA damage.
methodCognitive decline was determined by Montreal Cognitive Assessment (MoCA). Oxidative stress markers (malondialdehyde-MDA and superoxide dismutase-SOD) were determined and DNA damage was assayed using Alkaline Comet Assay. Toenail samples were taken and analyzed using ICP-MS to determine trace element levels.
resultsA total of 62.1 % of subjects had cognitive impairment. Subjects with cognitive impairment had significantly higher levels of MDA and DNA damage as compared to the group with normal cognitive function; MDA (2.07 ± 0.05 nmol/L vs 1.85 ± 0.06 nmol/L) (p<0.05) and DNA damage (% Tail Density, 14.52 ± 0.32 vs 10.31 ± 0.42; Tail Moment, 1.79 ± 0.06 vs 1.28 ± 0.06) (p<0.05 for all parameters). However, the level of SOD among subjects with cognitive impairment (6.67 ± 0.33 u.e/min/mg protein) was lower than the level among those with normal cognitive functions (11.36 ± 0.65 u.e/min/mg protein) (p<0.05). Multiple logistic regression revealed the predictors for cognitive impairment among the subjects were DNA damage (Adjusted odd ratio [OR], 1.37; 95% confidence interval [CI], 1.18-1.59), level of trace elements in toenails namely, lead (OR, 2.471; CI, 1.535-3.980) and copper (OR, 1.275; CI, 1.047-1.552) (p<0.05).
conclusionHigh levels of lead and copper can lead to increase in oxidative stress levels and are associated with DNA damage that eventually could be associated with cognitive decline.
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