ArticleScientific reports2017
Grand-maternal smoking in pregnancy and grandchild's autistic traits and diagnosed autism.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 82 citations in OpenAlex.
- Grandmother's pregnancy complications and autism spectrum disorders in grandchildren, a California multigenerational cohort study.JCPP advances · 2026Article
- Childhood trauma as a mediator between autistic traits and depression: Evidence from the ALSPAC birth cohort.Psychological medicine · 2026Article
- Associations of Autistic Traits and Autism with Incontinence and Constipation in a UK Birth Cohort.Journal of autism and developmental disorders · 2026Article
- Multigenerational smoking during pregnancy and risk of stillbirth: a population-based 3-generation cohort study.American journal of obstetrics and gynecology · 2026Article
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- Article
- Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study.Autism research : official journal of the International Society for Autism Research · 2025Article
- Multigenerational association between smoking and autism spectrum disorder: findings from a nationwide prospective cohort study.American journal of epidemiology · 2024Article
- Dopamine Dysregulation in Reward and Autism Spectrum Disorder.Brain sciences · 2024Review
- How life events may confer vulnerability to addiction: the role of epigenetics.Frontiers in molecular neuroscience · 2024Review
- A scoping review of multigenerational impacts of grandparental exposures on mental health in grandchildren.Current environmental health reports · 2023Article
- Learning and memory deficits produced by aspartame are heritable via the paternal lineage.Scientific reports · 2023Article
- Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis.Life science alliance · 2023Article
- Nicotine on the developing brain.Pharmacological research · 2023Review
- Cohort-guided insights into gene-environment interactions in autism spectrum disorders.Nature reviews. Neurology · 2023Review
- Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study.Molecular autism · 2022Article
- Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders.Journal of autism and developmental disorders · 2022Article
- Nicotine and the developing brain: Insights from preclinical models.Pharmacology, biochemistry, and behavior · 2022Article
- Genetic liability to rheumatoid arthritis on autism and autistic traits: polygenic risk score and Mendelian randomization analyses.Translational psychiatry · 2022Article
- Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice.Environmental epigenetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Although there is considerable research into the genetic background of autism spectrum disorders, environmental factors are likely to contribute to the variation in prevalence over time. Rodent experiments indicate that environmental exposures can have effects on subsequent generations, and human studies indicate that parental prenatal exposures may play a part in developmental variation. Here we use the Avon Longitudinal Study of Parents and Children (ALSPAC) to test the hypothesis that if the mother or father (F1) had been exposed to their own mother's (F0) smoking during pregnancy, the offspring (F2) would be at increased risk of autism. We find an association between maternal grandmother smoking in pregnancy and grand daughters having adverse scores in Social Communication and Repetitive Behaviour measures that are independently predictive of diagnosed autism. In line with this, we show an association with actual diagnosis of autism in her grandchildren. Paternal grandmothers smoking in pregnancy showed no associations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.