ArticleeLife2017
IL17 factors are early regulators in the gut epithelium during inflammatory response to
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 73 citations in OpenAlex.
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- Multiple evolutionary routes to immune diversification across animals.International immunology · 2026Review
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- CMTM4 is an adhesion modulator that regulates skeletal patterning and primary mesenchyme cell migration in sea urchin embryos.Developmental biology · 2025Article
- Exploring the Potential Mechanism of Liupao Tea Using UPLC-Q-TOF/MS and Network Pharmacology.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Characterization of cellular and molecular immune components of the painted white sea urchin Lytechinus pictus in response to bacterial infection.Immunology and cell biology · 2025Article
- The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms.Immunological reviews · 2024Review
- Article
- The IL-17 pathway intertwines with neurotrophin and TLR/IL-1R pathways since its domain shuffling origin.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The roles of ABCB1/P-glycoprotein drug transporters in regulating gut microbes and inflammation: insights from animal models, old and new.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Recombinant SpTransformer proteins bind to specific sites on sea urchin phagocytes and modulateFrontiers in immunology · 2024Article
- Solute carrier (SLC) expression reveals skeletogenic cell diversity.Developmental biology · 2023Article
- Exploring the Role of a Novel Interleukin-17 Homolog from Invertebrate Marine MusselInternational journal of molecular sciences · 2023Article
- Bald sea urchin disease shifts the surface microbiome on purple sea urchins in an aquarium.Pathogens and disease · 2023Article
- The Double Game Played by Th17 Cells in Infection: Host Defense and Immunopathology.Pathogens (Basel, Switzerland) · 2022Review
- Wound repair in sea urchin larvae involves pigment cells and blastocoelar cells.Developmental biology · 2022Article
- Pigmentation biosynthesis influences the microbiome in sea urchins.Proceedings. Biological sciences · 2022Article
- The complex set of internal repeats in SpTransformer protein sequences result in multiple but limited alternative alignments.Frontiers in immunology · 2022Article
- Live imaging of echinoderm embryos to illuminate evo-devo.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
- Commented on byA gut response.2017
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
IL17 cytokines are central mediators of mammalian immunity. In vertebrates, these factors derive from diverse cellular sources. Sea urchins share a molecular heritage with chordates that includes the IL17 system. Here, we characterize the role of epithelial expression of IL17 in the larval gut-associated immune response. The purple sea urchin genome encodes 10 IL17 subfamilies (35 genes) and 2 IL17 receptors. Most of these subfamilies are conserved throughout echinoderms. Two IL17 subfamilies are sequentially strongly upregulated and attenuated in the gut epithelium in response to bacterial disturbance. IL17R1 signal perturbation results in reduced expression of several response genes including an IL17 subtype, indicating a potential feedback. A third IL17 subfamily is activated in adult immune cells indicating that expression in immune cells and epithelia is divided among families. The larva provides a tractable model to investigate the regulation and consequences of gut epithelial IL17 expression across the organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.