ReviewNature reviews. Cardiology2017
Efficient design of clinical trials and epidemiological research: is it possible?
Review in Nature reviews. Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design.BMC medicine · 2018Guideline
- Women's Health Initiative Strong and Healthy (WHISH): A pragmatic physical activity intervention trial for cardiovascular disease prevention.Contemporary clinical trials · 2022Trial
- The SGLT2 inhibitor canagliflozin in heart failure: the CHIEF-HF remote, patient-centered randomized trial.Nature medicine · 2022 · on this mapTrial
- A Bayesian model with seasonal effects for predicting accrual in clinical trials: Application to HOBIT and BOOST-3 trials for severe traumatic brain injury.Contemporary clinical trials communications · 2025Article
- Clinical data mining: challenges, opportunities, and recommendations for translational applications.Journal of translational medicine · 2024Review
- Article
- Long-term health outcomes for patients with obstructive sleep apnea: placing the Agency for Healthcare Research and Quality report in context-a multisociety commentary.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Article
- Registry-based randomised clinical trials: a remedy for evidence-based diabetes care?Diabetologia · 2022Review
- Pragmatic Clinical Studies: An Emerging Clinical Research Discipline for Improving Evidence-Based Practice of Cardiovascular Diseases in Asia.Korean circulation journal · 2022Review
- Design and baseline characteristics of participants in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).Contemporary clinical trials · 2022Article
- When Can We Rely on Real-World Evidence to Evaluate New Medical Treatments?Clinical pharmacology and therapeutics · 2022Article
- When Can We Trust Real-World Data To Evaluate New Medical Treatments?Clinical pharmacology and therapeutics · 2022Article
- Zelen design clinical trials: why, when, and how.Trials · 2021Review
- Article
- Women's Health Initiative Strong and Healthy Pragmatic Physical Activity Intervention Trial for Cardiovascular Disease Prevention: Design and Baseline Characteristics.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Novel Trial Design: CHIEF-HF.Circulation. Heart failure · 2021Article
- Using digital technologies in clinical trials: Current and future applications.Contemporary clinical trials · 2021Article
- With great power comes great… reliability.European journal of heart failure · 2020Article
- Master Protocol Trial Design for Efficient and Rational Evaluation of Novel Therapeutic Oncology Devices.Journal of the National Cancer Institute · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Randomized clinical trials and large-scale, cohort studies continue to have a critical role in generating evidence in cardiovascular medicine; however, the increasing concern is that ballooning costs threaten the clinical trial enterprise. In this Perspectives article, we discuss the changing landscape of clinical research, and clinical trials in particular, focusing on reasons for the increasing costs and inefficiencies. These reasons include excessively complex design, overly restrictive inclusion and exclusion criteria, burdensome regulations, excessive source-data verification, and concerns about the effect of clinical research conduct on workflow. Thought leaders have called on the clinical research community to consider alternative, transformative business models, including those models that focus on simplicity and leveraging of digital resources. We present some examples of innovative approaches by which some investigators have successfully conducted large-scale, clinical trials at relatively low cost. These examples include randomized registry trials, cluster-randomized trials, adaptive trials, and trials that are fully embedded within digital clinical care or administrative platforms.
Indexed as
Identifiers
28447664What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.