ArticleNature2017
A chromosome conformation capture ordered sequence of the barley genome.
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Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 762 papers, 1 of them a synthesis that pooled it.
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762citing papers in PubMed, 1 pooled it
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Who cites it
762 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,541 citations in OpenAlex.
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- Article
702 more citing papers are in PubMed but not listed here.
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Authors and funding
76 authors at 20 institutions in 11 countries.
Martin MascherLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Heidrun GundlachPGSB - Plant Genome and Systems Biology, Helmholtz Center Munich - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Axel HimmelbachLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Sebastian BeierLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Sven O TwardziokPGSB - Plant Genome and Systems Biology, Helmholtz Center Munich - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Thomas WickerDepartment of Plant and Microbial Biology, University of Zurich, 8008 Zurich, Switzerland.
Volodymyr RadchukLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Christoph DockterCarlsberg Research Laboratory, 1799 Copenhagen, Denmark.
Pete E HedleyThe James Hutton Institute, Dundee DD2 5DA, UK.
Joanne RussellThe James Hutton Institute, Dundee DD2 5DA, UK.
Micha BayerThe James Hutton Institute, Dundee DD2 5DA, UK.
Luke RamsayThe James Hutton Institute, Dundee DD2 5DA, UK.
Hui LiuThe James Hutton Institute, Dundee DD2 5DA, UK.
Georg HabererPGSB - Plant Genome and Systems Biology, Helmholtz Center Munich - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Xiao-Qi ZhangSchool of Veterinary and Life Sciences, Murdoch University, Murdoch, WA6150, Australia.
Qisen ZhangAustralian Export Grains Innovation Centre, South Perth, WA6151, Australia.
Roberto A BarreroCentre for Comparative Genomics, Murdoch University, WA6150, Murdoch, Australia.
Lin LiDepartment of Agronomy and Plant Genetics, University of Minnesota, St. Paul, MN 55108, Minnesota, USA.
Stefan TaudienLeibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany.
Marco GrothLeibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany.
Marius FelderLeibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany.
Alex HastieBioNano Genomics Inc., San Diego, CA 92121, California, USA.
Hana ŠimkováInstitute of Experimental Botany, Centre of the Region Haná for Biotechnological and Agricultural Research, 78371 Olomouc, Czech Republic.
Helena StaňkováInstitute of Experimental Botany, Centre of the Region Haná for Biotechnological and Agricultural Research, 78371 Olomouc, Czech Republic.
Jan VránaInstitute of Experimental Botany, Centre of the Region Haná for Biotechnological and Agricultural Research, 78371 Olomouc, Czech Republic.
Saki ChanBioNano Genomics Inc., San Diego, CA 92121, California, USA.
María Muñoz-AmatriaínDepartment of Botany &Plant Sciences, University of California, Riverside, Riverside, CA 92521, California, USA.
Rachid OunitDepartment of Computer Science and Engineering, University of California, Riverside, Riverside, CA 92521 California, USA.
Steve WanamakerDepartment of Botany &Plant Sciences, University of California, Riverside, Riverside, CA 92521, California, USA.
Daniel BolserEuropean Molecular Biology Laboratory - The European Bioinformatics Institute, Hinxton CB10 1SD, UK.
Christian ColmseeLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Thomas SchmutzerLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Lala Aliyeva-SchnorrLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Stefano GrassoDepartment of Agricultural and Environmental Sciences, University of Udine, 33100 Udine, Italy.
Jaakko TanskanenGreen Technology, Natural Resources Institute (Luke), Viikki Plant Science Centre, and Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland.
Anna ChailyanCarlsberg Research Laboratory, 1799 Copenhagen, Denmark.
Dharanya SampathEarlham Institute, Norwich NR4 7UH, UK.
Darren HeavensEarlham Institute, Norwich NR4 7UH, UK.
Leah ClissoldEarlham Institute, Norwich NR4 7UH, UK.
Sujie CaoBGI-Shenzhen, Shenzhen, 518083, China.
Brett ChapmanCentre for Comparative Genomics, Murdoch University, WA6150, Murdoch, Australia.
Fei DaiCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Yong HanCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Hua LiBGI-Shenzhen, Shenzhen, 518083, China.
Xuan LiBGI-Shenzhen, Shenzhen, 518083, China.
Chongyun LinBGI-Shenzhen, Shenzhen, 518083, China.
John K McCookeCentre for Comparative Genomics, Murdoch University, WA6150, Murdoch, Australia.
Cong TanCentre for Comparative Genomics, Murdoch University, WA6150, Murdoch, Australia.
Penghao WangSchool of Veterinary and Life Sciences, Murdoch University, Murdoch, WA6150, Australia.
Songbo WangBGI-Shenzhen, Shenzhen, 518083, China.
Shuya YinCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Gaofeng ZhouSchool of Veterinary and Life Sciences, Murdoch University, Murdoch, WA6150, Australia.
Jesse A PolandKansas State University, Wheat Genetics Resource Center, Department of Plant Pathology and Department of Agronomy, Manhattan, KS 66506, Kansas, USA.
Matthew I BellgardCentre for Comparative Genomics, Murdoch University, WA6150, Murdoch, Australia.
Ljudmilla BorisjukLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Andreas HoubenLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Jaroslav DoleželInstitute of Experimental Botany, Centre of the Region Haná for Biotechnological and Agricultural Research, 78371 Olomouc, Czech Republic.
Sarah AylingEarlham Institute, Norwich NR4 7UH, UK.
Stefano LonardiDepartment of Computer Science and Engineering, University of California, Riverside, Riverside, CA 92521 California, USA.
Paul KerseyEuropean Molecular Biology Laboratory - The European Bioinformatics Institute, Hinxton CB10 1SD, UK.
Peter LangridgeSchool of Agriculture, University of Adelaide, Urrbrae, SA5064, Australia.
Gary J MuehlbauerDepartment of Agronomy and Plant Genetics, University of Minnesota, St. Paul, MN 55108, Minnesota, USA.
Matthew D ClarkEarlham Institute, Norwich NR4 7UH, UK.
Mario CaccamoEarlham Institute, Norwich NR4 7UH, UK.
Alan H SchulmanGreen Technology, Natural Resources Institute (Luke), Viikki Plant Science Centre, and Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland.
Klaus F X MayerPGSB - Plant Genome and Systems Biology, Helmholtz Center Munich - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Matthias PlatzerLeibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany.
Timothy J CloseDepartment of Botany &Plant Sciences, University of California, Riverside, Riverside, CA 92521, California, USA.
Uwe ScholzLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Mats HanssonDepartment of Biology, Lund University, 22362 Lund, Sweden.
Guoping ZhangCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Ilka BraumannCarlsberg Research Laboratory, 1799 Copenhagen, Denmark.
Manuel SpannaglPGSB - Plant Genome and Systems Biology, Helmholtz Center Munich - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Chengdao LiSchool of Veterinary and Life Sciences, Murdoch University, Murdoch, WA6150, Australia.
Robbie WaughThe James Hutton Institute, Dundee DD2 5DA, UK.
Nils SteinLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, 06466 Seeland, Germany.
Leibniz Institute of Plant Genetics and Crop Plant Research · DEMurdoch University · AUEarlham Institute · GBBGI Group (China) · CNJames Hutton Institute · GBUniversity of California, Riverside · USCzech Academy of Sciences, Institute of Experimental Botany · CZHelmholtz Zentrum München · DELeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DEZhejiang University · CNCarlsberg Laboratory · DKBioNano Genomics (United States) · USEuropean Bioinformatics Institute · GBUniversity of Minnesota · USAgriculture and Food · AUAustralian Export Grains Innovation Centre · AUKansas State University · USLund University · SENatural Resources Institute Finland · FIUniversity of Adelaide · AU
Funding
Biotechnology and Biological Sciences Research Council BB/H531519/1
Abstract
Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and large pericentromeric regions that are virtually devoid of meiotic recombination. Here we present a high-quality reference genome assembly for barley (Hordeum vulgare L.). We use chromosome conformation capture mapping to derive the linear order of sequences across the pericentromeric space and to investigate the spatial organization of chromatin in the nucleus at megabase resolution. The composition of genes and repetitive elements differs between distal and proximal regions. Gene family analyses reveal lineage-specific duplications of genes involved in the transport of nutrients to developing seeds and the mobilization of carbohydrates in grains. We demonstrate the importance of the barley reference sequence for breeding by inspecting the genomic partitioning of sequence variation in modern elite germplasm, highlighting regions vulnerable to genetic erosion.
Indexed as
Cell NucleusCentromereChromatinChromosome MappingChromosomes, Artificial, BacterialChromosomes, PlantGenetic VariationGenome, PlantGenomicsHaplotypesHordeumMeiosisRepetitive Sequences, Nucleic AcidSeedsChromatin
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