ArticlePharmaceutical biology2017
Anti-inflammatory and gastroprotective potential of leaf essential oil of Cinnamomum glanduliferum in ethanol-induced rat experimental gastritis.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Neuroprotective Potential ofBiomolecules · 2025Article
- Metabolomics, antioxidant, and enzyme inhibitory effects ofFrontiers in chemistry · 2025Article
- GC/MS Analysis and Protective Effects ofPlants (Basel, Switzerland) · 2024Article
- Metabolic profiling and enzyme inhibitory activity of the essential oil of citrus aurantium fruit peel.BMC complementary medicine and therapies · 2024Article
- The impact of seasonal variation on the composition of the volatile oil of Polyalthia suberosa (Roxb.) Thwaites leaves and evaluation of its acetylcholinesterase inhibitory activity.BMC complementary medicine and therapies · 2024Article
- Variation of the essential oil components of Citrus aurantium leaves upon using different distillation techniques and evaluation of their antioxidant, antidiabetic, and neuroprotective effect against Alzheimer's disease.BMC complementary medicine and therapies · 2024Article
- Use ofPeerJ · 2024Article
- Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies.Drug design, development and therapy · 2024Review
- Chemical Composition of theAntibiotics (Basel, Switzerland) · 2023Article
- Comprehensive Metabolite Profiling of Cinnamon (Life (Basel, Switzerland) · 2023Article
- GC/MS analysis and potential synergistic effect of mandarin and marjoram oils onJournal of enzyme inhibition and medicinal chemistry · 2022Article
- Article
- Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy.Scientific reports · 2022Article
- GC/MS Profiling, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase and Anti-Hyaluronidase Activities of aPlants (Basel, Switzerland) · 2022Article
- Gastroprotective Effect of MicroencapsulatedMolecules (Basel, Switzerland) · 2022Article
- Pharmacological Effects ofBiomolecules · 2020Article
- The plastid genome of a spice plantsMitochondrial DNA. Part B, Resources · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextNothing could be found in the literature concerning Cinnamomum glanduliferum (Wall) Meissn (Lauraceae) bark (CG) in Egypt.
objectiveTo investigate CG volatile oil chemically and its anti-inflammatory and gastroprotective effects. MATERIALS AND
methodsEssential oils were investigated by GC-MS. Leaves oil was assessed at doses of 250, 500 and 1000 mg/kg for its anti-inflammatory effect against carrageenan-induced rat oedema model. Serum inflammation markers were measured. The gastro-protective effect of the same doses of the volatile oil was also tested in ethanol-induced non-ulcerative gastritis model in rats. Stomach oxidative stress markers were examined following 1 h after intragastric ethanol administration.
resultsTwenty-five and 20 compounds were identified from leaf and branch oils, respectively (98.85 and 99.13%). The major ones were: eucalyptol (59.44%; 55.74%), sabinene (14.99%; 7.12%), α-terpineol (6.44%; 9.81%), α-pinene (5.27%; 4.71%). Following 4 h of treatment leaves volatile oil at doses of 250, 500 and 1000 mg/kg significantly reduced paw volume to 94, 82 and 69%, respectively. The same doses significantly reduced COX-2 activity to 73.8, 50.7 and 21.4 nmol/min/mL, respectively. A significant reduction of PGE2 concentration was observed (2.95 ± 0.2, 2.45 ± 0.15 and 1.75 ± 0.015 pg/mL). CG oil exhibited a significant modulatory effect on ethanol-induced gastritis in rats as the level of NO reduced to 32, 37 and 41 μM nitrate/g and also a significant inhibition of lipid peroxidation was observed via reduction of MDA concentration (1.15, 1.11 and 1.04 nmol/g).
conclusionCG volatile oil exhibited an anti-inflammatory effect and protected against ethanol-induced non-ulcerative gastritis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.