ArticleInternational journal of bipolar disorders2017
Article in International journal of bipolar disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- MS-based metabolic profiling in serum for bipolar disorder.Metabolic brain disease · 2026Article
- Discrimination of Bipolar Disorder and Schizophrenia Patients Based on LC-HRMS Lipidomics.Metabolites · 2026Article
- Metabolomic biomarkers of psychotic conversion in ultra-high-risk subjects: a pilot study.Translational psychiatry · 2025Article
- Biomarkers of bipolar disorder in omics and neuroimaging.Journal of pharmaceutical analysis · 2025Review
- LC-HRMS Lipidomic Fingerprints in Serbian Cohort of Schizophrenia Patients.International journal of molecular sciences · 2024Article
- Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia.International journal of molecular sciences · 2023Article
- Compound-Specific 1DACS omega · 2023Article
- Metabolomic Profiling of Bipolar Disorder byMetabolites · 2023Article
- Comparing the metabolic pathways of different clinical phases of bipolar disorder through metabolomics studies.Frontiers in psychiatry · 2023Article
- Metabolomic biomarkers related to non-suicidal self-injury in patients with bipolar disorder.BMC psychiatry · 2022Article
- A system biology approach based on metabolic biomarkers and protein-protein interactions for identifying pathways underlying schizophrenia and bipolar disorder.Scientific reports · 2021Article
- Effects of Psychostimulants and Antipsychotics on Serum Lipids in an Animal Model for Schizophrenia.Biomedicines · 2021Article
- Metabolic Profiling in Bipolar Disorder Patients During Depressive Episodes.Frontiers in psychiatry · 2020Article
- Metabolomics Biomarkers for Precision Psychiatry.Advances in experimental medicine and biology · 2019Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics.
methodsMetabolomic profiling, employing
resultsThe investigated groups presented distinct metabolic profiles, in which the main differential metabolites found in the serum sample of bipolar disorder patients compared with those from controls were lipids, lipid metabolism-related molecules (choline, myo-inositol), and some amino acids (N-acetyl-L-phenyl alanine, N-acetyl-L-aspartyl-L-glutamic acid, L-glutamine). In addition, amygdalin, α-ketoglutaric acid, and lipoamide, among other compounds, were also present or were significantly altered in the serum of bipolar disorder patients. The data presented herein suggest that some of these metabolites differentially distributed between the groups studied may be directly related to the bipolar disorder pathophysiology.
conclusionsThe strategy employed here showed significant potential for exploring pathophysiological features and molecular pathways involved in bipolar disorder. Thus, our findings may contribute to pave the way for future studies aiming at identifying important potential biomarkers for bipolar disorder diagnosis or progression follow-up.
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