Evidence map›Paper›PMID 28447283›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019

Adenosine stress myocardial perfusion imaging in octogenarians: Safety, tolerability, and long-term prognostic implications of hemodynamic response and SPECT-related variables.

Athanasios Katsikis, Athanasios Theodorakos, Spyridon Papaioannou, Antonios Kalkinis, Genovefa Kolovou, Konstantinos Konstantinou, Maria Koutelou

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Update of the Brazilian Guideline on Nuclear Cardiology - 2020.Arquivos brasileiros de cardiologia · 2020
    Guideline
  2. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2019: Single-photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Review
  3. Adenosine MPS in octogenarians: Looking safely into the future.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  4. Role of myocardial perfusion scintigraphy in octogenarians: Time for reappraisal?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Athanasios KatsikisNuclear Medicine Department, Onassis Cardiac Surgery Center, Athens, Greece. tkatsikis@gmail.com.
Athanasios TheodorakosNuclear Medicine Department, Onassis Cardiac Surgery Center, Athens, Greece.
Spyridon PapaioannouNuclear Medicine Department, Onassis Cardiac Surgery Center, Athens, Greece.
Antonios KalkinisNuclear Medicine Department, Onassis Cardiac Surgery Center, Athens, Greece.
Genovefa KolovouCardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
Konstantinos KonstantinouCardiology Department, 401 General Military Hospital of Athens, Athens, Greece.
Maria KoutelouNuclear Medicine Department, Onassis Cardiac Surgery Center, Athens, Greece.
Onassis Cardiac Surgery Center · GR401 General Military Hospital of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvaluation of tolerability, safety, and prognostic implications of adenosine stress myocardial perfusion imaging (MPI) in octogenarians.

methods370 octogenarians (49% known coronary artery disease) were studied. Hemodynamic response, MPI-related data, and rest-left ventricular ejection fraction (LVEF) based on echocardiography were registered per patient, and prospective follow-up was performed to document all-cause death (ACD), cardiac death (CD), myocardial infarction (MI), and late revascularization.

resultsNo deaths or MIs were observed during adenosine infusion or the short-term post-infusion period. 86% of patients were able to tolerate a 6-minute infusion. All side effects terminated spontaneously after infusion cessation, except for one case of pulmonary oedema. After 9.3 years, there were 124 ACDs, 62 CDs, 16 MIs, and 35 revascularizations. Differences between survival curves of summed stress score (SSS)-based risk groups were significant for all end points (P < .001). SSS and LVEF were independent predictors of all end points (P ≤ .01) and lung uptake of cardiac end points. ΔHR <10 bpm (OR = 1.78, P = .004) and inability to increase HR by >10 bpm and decrease systolic blood pressure by >10 mmHg (OR = 2, P = .02) during adenosine infusion were independent predictors of ACD and CD, respectively. Hemodynamic response variables, SSS, and lung uptake provided incremental prognostic value over pre-test data for ACD and CD.

conclusionsIn octogenarians, adenosine stress MPI is well tolerated and provides effective long-term risk stratification.

Indexed as

Myocardial Perfusion ImagingTomography, Emission-Computed, Single-PhotonAdenosineAged, 80 and overCoronary Artery DiseaseEchocardiographyFemaleHeart VentriclesHemodynamicsHumansMaleMyocardial InfarctionPatient SafetyPrognosisProspective StudiesRegistriesAdenosineadenosinemyocardial perfusion imagingOctogenariansrisk stratificationsafety

Identifiers

PMID28447283
OpenAlexW2609281284

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.