Evidence map›Paper›PMID 28447191›Full record

ReviewVirus genes2017

The human cytomegalovirus chemokine receptor homolog encoded by US27.

James R Stegman, Barry J Margulies

Abstract readReview
PubMed Publisher
In one paragraph

Review in Virus genes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

James R StegmanTowson University Herpes Virus Lab, Towson University Department of Biology, Towson, MD, USA.
Barry J MarguliesTowson University Herpes Virus Lab, Towson University Department of Biology, Towson, MD, USA. bjmarg@alum.mit.edu.ORCID http://orcid.org/0000-0002-0042-0676
Johns Hopkins University · USTowson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genome of human cytomegalovirus contains four genes that encode chemokine receptor homologs. Of these, the protein encoded by US27 is of particular interest today because it is currently one of the viral G-protein coupled receptors that remain classified as an orphan receptor. This review explains what is presently understood about this glycoprotein: its biochemistry, its location in infected cells, and its apparent function. While there are still many questions that remain about these topics and more, we also discuss the utility of the US27-encoded glycoprotein as a new target for antiviral intervention.

Indexed as

AnimalsCytomegalovirusCytomegalovirus InfectionsHost-Pathogen InteractionsHumansReceptors, ChemokineViral ProteinsReceptors, ChemokineUS27 protein, human cytomegalovirusViral ProteinsChemokine receptorGPCRHuman cytomegalovirusMembrane proteinsUL33US27

Identifiers

PMID28447191
OpenAlexW2607983889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.