Evidence map›Paper›PMID 28446860›Full record

ArticleMolecular vision2017

UVB promotes the initiation of uveitic inflammatory injury in vivo and is attenuated by UV-blocking protection.

Yi-Ching Shao, Jyh-Cheng Liou, Chan-Yen Kuo, Yun-Shan Tsai, En-Chieh Lin, Ching-Ju Hsieh, Si-Ping Lin, Bo-Yie Chen

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Molecular vision, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. P1G10, the Proteolytic Fraction fromInternational journal of molecular sciences · 2019
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Yi-Ching ShaoDepartment of Ophthalmology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Jyh-Cheng LiouDepartment of Ophthalmology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chan-Yen KuoInstitute of Systems Biology and Bioinformatics, National Central University, Jhongli, Taiwan.
Yun-Shan TsaiDepartment of Optometry, Chung Shan Medical University, Taichung, Taiwan.
En-Chieh LinInstitute of Optometry, Chung Shan Medical University, Taichung, Taiwan.
Ching-Ju HsiehDepartment of Ophthalmology, Taipei City Hospital, Taipei, Taiwan.
Si-Ping LinDepartment of Optometry, Chung Shan Medical University, Taichung, Taiwan.
Bo-Yie ChenDepartment of Ophthalmology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chung Shan Medical University · TWChung Shan Medical University Hospital · TWNational Central University · TWTaipei City Hospital · TWUniversity of Kang Ning · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUveitic inflammatory injury can cause irreversible visual loss; however, no single animal model recapitulates all the characteristics of human uveitis. Ultraviolet radiation (UVR) is one of the risk factors for uveitis, but the role of UVR in the pathogenesis of uveitic injury is unclear. The aim of this study was to elucidate whether UVB promotes the initiation of, and subsequently contributes to, uveitic inflammatory injury.

methodsMice were assigned to either a blank control group or one of three UVB treatment groups: no protection, protection with Nelfilcon A contact lens (Food and Drug Administration [FDA] class II, about 46.8% UVB transmittance), or protection with Etafilcon A contact lens (FDA class IV, about 0.55% UVB transmittance). The contact lenses acted as blocking barriers against UVR. After the application of UVR, pathologic injuries were determined with slit-lamp microscopy and histologic examination.

resultsCompared with the intact status of the controls, the anterior eyes of the UVB groups showed pathologic alterations in physiologic properties and tissue integrity. UVR promoted anterior uveitic inflammatory injury, with expansion of the hyperemic iris vessels, over-production of aqueous humor protein, disruption of the blood-aqueous barrier, and embedding of infiltrative leukocytes inside the iridocorneal angle. However, blockage of UVR in vivo retarded the progression of uveitic inflammatory injury. The highest level of UV protection in the Etafilcon A group resulted in greater inhibition of uveitic inflammatory injury than that in the Nelfilcon A group.

conclusionsThis study demonstrates that UVB initiated and promoted uveitic inflammatory injury. UV protection is needed for the clinical management of anterior uveitis. The Etafilcon A lenses provide better protection of the anterior segment of the eye against UVB damage compared with the Nelfilcon A lenses.

Indexed as

Contact Lenses, HydrophilicCorneal DiseasesRadiation Injuries, ExperimentalUveitis, AnteriorAnimalsAnterior Eye SegmentFemaleMethacrylatesMiceMice, Inbred ICRRadiation ProtectionUltraviolet RaysetafilconMethacrylates

Identifiers

PMID28446860
PMCPMC5390783
OpenAlexW2702306198

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.