Evidence map›Paper›PMID 28446810›Full record

ReviewNature reviews. Rheumatology2017

Pathogenesis of ankylosing spondylitis - recent advances and future directions.

Vidya Ranganathan, Eric Gracey, Matthew A Brown, Robert D Inman, Nigil Haroon

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vidya RanganathanKrembil Research Institute, University Health Network, 1-60 Leonard Avenue, Toronto, Ontario M5T 2S8, Canada.
Eric GraceyKrembil Research Institute, University Health Network, 1-60 Leonard Avenue, Toronto, Ontario M5T 2S8, Canada.
Matthew A BrownInstitute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Queensland 4001, Australia.
Robert D InmanKrembil Research Institute, University Health Network, 1-60 Leonard Avenue, Toronto, Ontario M5T 2S8, Canada.
Nigil HaroonKrembil Research Institute, University Health Network, 1-60 Leonard Avenue, Toronto, Ontario M5T 2S8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past 5 years, advances in high-throughput techniques and studies involving large cohorts of patients have led to considerable advances in the identification of novel genetic associations and immune pathways involved in ankylosing spondylitis (AS). These discoveries include genes encoding cytokine receptors, transcription factors, signalling molecules and transport proteins. Although progress has been made in understanding the functions and potential pathogenic roles of some of these molecules, much work remains to be done to comprehend their complex interactions and therapeutic potential in AS. In this Review, we outline the current knowledge of AS pathogenesis, including genetic risk associations, HLA-B27-mediated pathology, perturbations in antigen-presentation pathways and the contribution of the type 3 immune response.

Indexed as

Antigen PresentationHumansInterleukin-17Spondylitis, AnkylosingInterleukin-17

Identifiers

PMID28446810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.