ArticleJournal of virology2017
Salivary Blockade Protects the Lower Respiratory Tract of Mice from Lethal Influenza Virus Infection.
Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Dissemination of influenza B virus to the lower respiratory tract of mice is restricted by the interferon response.Journal of virology · 2024Article
- Dissemination of influenza B virus to the lower respiratory tract of mice is restricted by the interferon response.Journal of virology · 2024Article
- Interferon signaling in the nasal epithelium distinguishes among lethal and common cold coronaviruses and mediates viral clearance.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Interferon signaling in the nasal epithelium distinguishes among lethal and common cold respiratory viruses and is critical for viral clearance.bioRxiv : the preprint server for biology · 2023Article
- Progress in salivary glands: Endocrine glands with immune functions.Frontiers in endocrinology · 2023Review
- Pulsed blue light, saliva and curcumin significantly inactivate human coronavirus.Journal of photochemistry and photobiology. B, Biology · 2022Article
- The Impact of Oral Health on Respiratory Viral Infection.Dentistry journal · 2021Review
- TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs.JCI insight · 2021Article
- Quantifying between-Host Transmission in Influenza Virus Infections.Cold Spring Harbor perspectives in medicine · 2020Review
- Mesoscale All-Atom Influenza Virus Simulations Suggest New Substrate Binding Mechanism.ACS central science · 2020Article
- Inhibition of Influenza A Virus by Human Infant Saliva.Viruses · 2019Article
- Influenza Virus Neuraminidase Structure and Functions.Frontiers in microbiology · 2019Review
- Article
- IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission.eLife · 2018Article
- Mouse Saliva Inhibits Transit of Influenza Virus to the Lower Respiratory Tract by Efficiently Blocking Influenza Virus Neuraminidase Activity.Journal of virology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is possible to model the progression of influenza virus from the upper respiratory tract to the lower respiratory tract in the mouse using viral inoculum delivered in a restricted manner to the nose. In this model, infection with the A/Udorn/307/72 (Udorn) strain of virus results ultimately in high viral titers in both the trachea and lungs. In contrast, the A/Puerto Rico/8/34 (PR8) strain causes an infection that is almost entirely limited to the nasal passages. The factors that govern the progression of virus down the respiratory tract are not well understood. Here, we show that, while PR8 virus grows to high titers in the nose, an inhibitor present in the saliva blocks further progression of infection to the trachea and lungs and renders an otherwise lethal dose of virus completely asymptomatic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.