ArticleNeurology2017
Relationship between carotid arterial properties and cerebral white matter hyperintensities.
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In one paragraph
Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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29citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2023Pooled it
- Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.Frontiers in neurology · 2019Pooled it
- Cross-organ analysis reveals associations between vascular properties of the retina, the carotid and aortic arteries, and the brain.Communications medicine · 2026Article
- High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later.Neurobiology of aging · 2025Article
- Associations of aortic and carotid artery health with cerebrovascular markers and cognition in older adults from the Whitehall II imaging study.BMC medicine · 2025Article
- Cerebral arterial lumens are enlarged in children and young adults with sickle cell disease compared to peers.Neuroimage. Reports · 2025Article
- WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study.Stroke · 2025Review
- Shear Wave Elastography for Carotid Artery Stiffness: Ready for Prime Time?Diagnostics (Basel, Switzerland) · 2025Review
- Deep learning-based prediction of cerebral white matter hyperintensity burden using carotid magnetic resonance angiography.Frontiers in neurology · 2025Article
- White matter hyperintensities in diverse populations: A systematic review of literature in the United States.Cerebral circulation - cognition and behavior · 2024Review
- Racial and ethnic influences on carotid atherosclerosis: Epidemiology and risk factors.SAGE open medicine · 2024Review
- The correlation between intracranial atherosclerosis and white matter hyperintensities in cerebral small vessel disease: a high-resolution magnetic resonance imaging study.Frontiers in neurology · 2024Article
- Cerebrovascular pulsatility indicates preoperative subcortical cognitive impairment and an increased risk for postoperative delirium in elderly patients undergoing elective spine surgery.Frontiers in medicine · 2024Article
- Vascular Cognitive Impairment (VCI).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Accelerated vascular aging: Ethnic differences in basilar artery length and diameter, and its association with cardiovascular risk factors and cerebral small vessel disease.Frontiers in cardiovascular medicine · 2022Article
- Contribution of intracranial artery stenosis to white matter hyperintensities progression in elderly Chinese patients: A 3-year retrospective longitudinal study.Frontiers in neurology · 2022Article
- Cardiovascular damage phenotypes and all-cause and CVD mortality in older adults.Annals of epidemiology · 2021Article
- Relationship Between Central Artery Stiffness, Brain Arterial Dilation, and White Matter Hyperintensities in Older Adults: The ARIC Study-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2021Observational
- Cerebral Hemodynamics and Carotid Atherosclerosis in Patients With Subcortical Ischemic Vascular Dementia.Frontiers in aging neuroscience · 2021Article
- Association of Carotid Atherosclerosis With White Matter Hyperintensity in an Asymptomatic Japanese Population: A Cross-Sectional Study.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Tatjana RundekFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis.
David Della-MorteFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis. ddellamorte@med.miami.edu.
Hannah GardenerFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis.
Chuanhui DongFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis.
Matthew S MarkertFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis.
Jose GutierrezFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis.
Eugene RobertsFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis.
Mitchell S V ElkindFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis.
Charles DeCarliFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis.
Ralph L SaccoFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis.
Clinton B WrightFrom the Evelyn F. McKnight Brain Institute (T.R., C. Dong, R.L.S., C.B.W.), Department of Neurology (T.R., D.D.-M., H.G., C. Dong, E.R., R.L.S., C.B.W.), and Department of Public Health Sciences (T.R., R.L.S., C.B.W.), Miller School of Medicine, University of Miami, FL; Department of Systems Medicine (D.D.-M.), School of Medicine, University of Rome Tor Vergata; San Raffaele Roma Open University (D.D.-M.), Rome, Italy; Department of Neurology (M.S.M.), Kansas University Medical Center, Kansas City; Department of Neurology (J.G., M.S.V.E.), College of Physicians and Surgeons, and Department of Epidemiology (J.G., M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; and Department of Neurology and Center for Neuroscience (C. DeCarli), University of California Davis.
Columbia University · USUniversity of Kansas Medical Center · USUniversity of Rome Tor Vergata · ITSan Raffaele University of Rome · IT
Funding
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI JIN, LEE-WAY · 1991 to 2020
$28.3MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MSTROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2MStroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1MGenetics Determinants of Extreme Phenotypes of Subclinical AtherosclerosisK24NS062737 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA · 2009 to 2013
$975kVascular Risk and Cognition in a Multi-ethnic CohortK02NS059729 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WRIGHT, CLINTON B · 2008 to 2013
$793kNIA NIH HHS P30 AG010129NINDS NIH HHS K02 NS059729NINDS NIH HHS K24 NS062737NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS029993NINDS NIH HHS R37 NS029993
Abstract
objectiveSince arterial stiffness is a functional measure of arterial compliance and may be an important marker of cerebrovascular disease, we examined the association of carotid artery stiffness with white matter hyperintensity volume (WMHV) in a cross-sectional study of 1,166 stroke-free participants.
methodsCarotid beta stiffness index (STIFF) was assessed by M-mode ultrasound of the common carotid artery and calculated as the ratio of natural log of the difference between systolic and diastolic blood pressure over STRAIN, a ratio of the difference between carotid systolic and diastolic diameter (DD) divided by DD. WMHV was measured by fluid-attenuated inversion recovery MRI. The associations of STIFF, DD, and STRAIN with WMHV were examined using linear regression after adjusting for sociodemographic, lifestyle, and vascular risk factors.
resultsIn a fully adjusted model, larger carotid DD was significantly associated with greater log-WMHV (β = 0.09,
conclusionsLarge carotid artery diameters are associated with greater burden of white matter hyperintensity (WMH) in this multiethnic population. The association between increased diameters, decreased STRAIN, and greater WMH burden is more pronounced among Hispanics. These associations suggest a potential important pathophysiologic role of extracranial large artery remodeling in the burden of WMH.
Indexed as
Vascular StiffnessAgedBlood PressureCarotid ArteriesCross-Sectional StudiesFemaleHumansLife StyleLinear ModelsMagnetic Resonance ImagingMaleNew YorkOrgan SizeProspective StudiesRisk FactorsSocioeconomic Factors
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