Evidence map›Paper›PMID 28446608›Full record

ArticleThe Journal of biological chemistry2017

Model-enabled gene search (MEGS) allows fast and direct discovery of enzymatic and transport gene functions in the marine bacterium

Shu Pan, Kiel Nikolakakis, Paul A Adamczyk, Min Pan, Edward G Ruby, Jennifer L Reed

Open access · hybridAbstract readComparative StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Shu PanFrom the Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Kiel NikolakakisFrom the Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Paul A AdamczykFrom the Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Min Panthe School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China, and.
Edward G Rubythe Pacific Biosciences Research Center, University of Hawaii, Manoa, Hawaii 96813.
Jennifer L ReedFrom the Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, jennifer.reed@wisc.edu.
University of Wisconsin–Madison · USSoutheast University · CNUniversity of Hawaiʻi at Mānoa · US

Funding

Vibrio fischeri as a Model for Bacterial ColonizationR37AI050661 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI MARGARET J MC FALL-NGAI, Edward G Ruby · 2018 to 2026
$5.4M
Vibrio fischeri as a model of Bacterial ColonizationR01AI050661 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MC FALL-NGAI, MARGARET J, RUBY, EDWARD G · 2002 to 2016
$5.0M
Vibrio Virulence Determinants in a Benign ColonizationR01OD011024 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MC FALL-NGAI, MARGARET J, RUBY, EDWARD G · 2012 to 2020
$3.9M
Chemotactic Cues in the Symbiosis Between Vibrio fischeri and Euprymna scolopesF32GM112214 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI NIKOLAKAKIS, KIEL · 2014 to 2016
$112k
NIAID NIH HHS R01 AI050661NIAID NIH HHS R37 AI050661NIGMS NIH HHS F32 GM112214NIH HHS R01 OD011024
6 · The paper itself

Abstract

Whereas genomes can be rapidly sequenced, the functions of many genes are incompletely or erroneously annotated because of a lack of experimental evidence or prior functional knowledge in sequence databases. To address this weakness, we describe here a

Indexed as

Expert SystemsModels, GeneticAliivibrio fischeriAnimalsAquacultureAquatic OrganismsBacterial ProteinsComputer SimulationDecapodiformesEscherichia coliGene DeletionGenetic Complementation TestGenomic LibraryGenomicsHawaiiHigh-Throughput Nucleotide SequencingBacterial ProteinsRecombinant Proteinsbacterial metabolismcomputational biologyconstraint-based modelenzyme selectionfunctional genomicsgenome annotationgenome-scale modelingmetabolismsystems biology

Identifiers

PMID28446608
PMCPMC5473228
OpenAlexW2608970443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.