Evidence map›Paper›PMID 28446598›Full record

ArticleGenes & development2017

The histone variant H2A.Z promotes efficient cotranscriptional splicing in

Lauren T Neves, Stephen Douglass, Roberto Spreafico, Srivats Venkataramanan, Tracy L Kress, Tracy L Johnson

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Nascent RNA and the Coordination of Splicing with Transcription.Cold Spring Harbor perspectives in biology · 2019
    Review
  18. Article
  19. Pre-mRNA Splicing in the Nuclear Landscape.Cold Spring Harbor symposia on quantitative biology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lauren T NevesDepartment of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, Los Angeles, California, 90095 USA.
Stephen DouglassDepartment of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, Los Angeles, California, 90095 USA.
Roberto SpreaficoInstitute for Quantitative and Computational Biosciences, University of California at Los Angeles, Los Angeles, California 90095, USA.
Srivats VenkataramananDepartment of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, Los Angeles, California, 90095 USA.
Tracy L KressDepartment of Biology, The College of New Jersey, Ewing, New Jersey 08628, USA.
Tracy L JohnsonDepartment of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, Los Angeles, California, 90095 USA.
University of California, Los Angeles · USCollege of New Jersey · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
"Ribonomics" of Gene Regulation to predict Innate Immune ResponsesU01HG007912 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BLACK, DOUGLAS L, HOFFMANN, ALEXANDER · 2015 to 2017
$5.8M
Eukaryotic RNA Processing and Chromatin ModificationR01GM085474 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOHNSON, TRACY L · 2010 to 2021
$2.6M
Reciprocal coupling between RNA splicing and transcription through chromatin dynamicsR15GM122026 · NIGMS · COLLEGE OF NEW JERSEY · PI KRESS, TRACY · 2016 to 2016
$395k
NHGRI NIH HHS U01 HG007912NIGMS NIH HHS R01 GM085474NIGMS NIH HHS R15 GM122026NIGMS NIH HHS T32 GM007185
6 · The paper itself

Abstract

In eukaryotes, a dynamic ribonucleic protein machine known as the spliceosome catalyzes the removal of introns from premessenger RNA (pre-mRNA). Recent studies show the processes of RNA synthesis and RNA processing to be spatio-temporally coordinated, indicating that RNA splicing takes place in the context of chromatin. H2A.Z is a highly conserved histone variant of the canonical histone H2A. In

Indexed as

Gene Expression Regulation, FungalRNA SplicingTranscription, GeneticHistonesIntronsNucleosomesPromoter Regions, GeneticRibonucleoprotein, U2 Small NuclearRNA PrecursorsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSpliceosomesHistonesHtz1 protein, S cerevisiaeNucleosomesRibonucleoprotein, U2 Small NuclearRNA PrecursorsSaccharomyces cerevisiae Proteinsbudding yeastchromatinH2A.ZHTZ1pre-mRNA splicingRNA processingSwr1

Identifiers

PMID28446598
PMCPMC5411710
OpenAlexW2609155983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.