Evidence map›Paper›PMID 28446597›Full record

ArticleGenes & development2017

The histone variant H2A.Z promotes splicing of weak introns.

Kelly E Nissen, Christina M Homer, Colm J Ryan, Michael Shales, Nevan J Krogan, Kristin L Patrick, Christine Guthrie

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Nascent RNA and the Coordination of Splicing with Transcription.Cold Spring Harbor perspectives in biology · 2019
    Review
  12. Pre-mRNA Splicing in the Nuclear Landscape.Cold Spring Harbor symposia on quantitative biology · 2019
    Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Kelly E NissenDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco 94158, California, USA.
Christina M HomerDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco 94158, California, USA.
Colm J RyanSystems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
Michael ShalesDepartment of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco 94158, California, USA.
Nevan J KroganDepartment of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco 94158, California, USA.
Kristin L PatrickDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco 94158, California, USA.
Christine GuthrieDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco 94158, California, USA.
University of California, San Francisco · USQB3 · USTexas A&M Health Science Center · USUniversity College Dublin · IE

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Rewiring Therapeutic Cells: User-Controlled T Cells and Stem CellsP50GM081879 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, WENDELL A · 2010 to 2017
$19.0M
BIOSYNTHESIS OF RNASR01GM021119 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUTHRIE, CHRISTINE · 1985 to 2015
$12.9M
Comparative Analysis of Genetic Interaction NetworksR01GM084279 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY, KROGAN, NEVAN J · 2008 to 2017
$3.9M
Genetic Analysis of the Nucleosome and RNA Polymerase II: A Systems ApproachR01GM084448 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KROGAN, NEVAN J · 2008 to 2012
$2.3M
Integrating computation and genetics to quantify specificity in protein networksR01GM098101 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA, KROGAN, NEVAN J · 2011 to 2014
$1.7M
Capsular-Independent Inhibition of Phagocytosis by Cryptococcus neoformansF30HL120496 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOMER, CHRISTINA · 2014 to 2016
$83k
BIOSYNTHESIS OF RNASR37GM021119 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI GUTHRIE, CHRISTINE · 1990 to 1999
–
NHLBI NIH HHS F30 HL120496NIGMS NIH HHS P50 GM081879NIGMS NIH HHS R01 GM021119NIGMS NIH HHS R01 GM084279NIGMS NIH HHS R01 GM084448NIGMS NIH HHS R01 GM098101NIGMS NIH HHS R37 GM021119NIGMS NIH HHS T32 GM007618Wellcome TrustWellcome Trust 103049/Z/13/Z
6 · The paper itself

Abstract

Multiple lines of evidence implicate chromatin in the regulation of premessenger RNA (pre-mRNA) splicing. However, the influence of chromatin factors on cotranscriptional splice site usage remains unclear. Here we investigated the function of the highly conserved histone variant H2A.Z in pre-mRNA splicing using the intron-rich model yeast

Indexed as

IntronsRNA SplicingAdenosine TriphosphatasesGene Expression Regulation, FungalHistonesNucleosomesPromoter Regions, GeneticSchizosaccharomycesSchizosaccharomyces pombe ProteinsSpliceosomesAdenosine TriphosphatasesHistonesNucleosomesSchizosaccharomyces pombe Proteinschromatinfission yeastH2A.Zpre-mRNA splicingPrp16Swr1 complex

Identifiers

PMID28446597
PMCPMC5411709
OpenAlexW2609594954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.