Evidence map›Paper›PMID 28446504›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Feasibility of Ultra-High-Throughput Functional Screening of Melanoma Biopsies for Discovery of Novel Cancer Drug Combinations.

Adam A Friedman, Yun Xia, Lorenzo Trippa, Long Phi Le, Vivien Igras, Dennie T Frederick, Jennifer A Wargo, Kenneth K Tanabe, Donald P Lawrence, Donna S Neuberg and 2 more

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. A Pan-Cancer Ex Vivo Drug Screen Atlas for Functional Precision Oncology.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Annual review of cancer biology · 2021
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Adam A FriedmanMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Yun XiaDermatology and Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts.
Lorenzo TrippaDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Long Phi LeMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Vivien IgrasMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Dennie T FrederickMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Jennifer A WargoMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Kenneth K TanabeMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Donald P LawrenceMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Donna S NeubergDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Keith T FlahertyMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
David E FisherMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. dfisher3@partners.org.

Funding

Transcriptional mechanisms and melanomaP01CA163222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LEONARD Ira ZON · 2013 to 2026
$25.3M
Role of Tumor Stroma in Therapeutic Response and ResistanceU54CA163125 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FLAHERTY, KEITH T, FLAHERTY, KEITH T · 2011 to 2015
$4.4M
Exploring synergy of combined BRAF-targeted therapy & immunotherapy for melanomaK08CA160692 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WARGO, JENNIFER A. · 2012 to 2016
$713k
Development of next-generation cancer functional diagnosticsR21CA175907 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FISHER, DAVID E · 2013 to 2014
$411k
NCI NIH HHS K08 CA160692NCI NIH HHS P01 CA163222NCI NIH HHS R21 CA175907NCI NIH HHS U54 CA163125
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntineoplastic Combined Chemotherapy ProtocolsBiopsyDrug DiscoveryFeasibility StudiesFemaleHigh-Throughput Screening AssaysHumansIndolesMelanomaMiceMice, Inbred NODMice, KnockoutMice, SCIDQuinazolinesSulfonamidescediranibIndolesPLX 4720QuinazolinesSulfonamides

Identifiers

PMID28446504
PMCPMC5559310

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.