Trial reportJournal of the American Heart Association2017
Randomized Controlled Trial of High-Volume Energy Drink Versus Caffeine Consumption on ECG and Hemodynamic Parameters.
Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Energy Drink Consumption on ECG and Hemodynamic Parameters in Young Healthy Volunteers
Comparison of Synthetic and Natural Caffeine on Hemodynamic Parameters in Young, Healthy Volunteers: A Randomized, Double Blind, Crossover Study
The Effect of Energy Drink on Cardiovascular Variables: A Randomized Controlled Trial
The Effect of Energy Drink Ingredients on Cardiovascular Function
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Energy Drinks as the Legal Cocaine? A Comparative Review of Cardiac Physiopathological and Histopathological Patterns.Cardiovascular toxicology · 2025Pooled it
- Pooled it
- Trial
- Effects of Mixing Energy Drinks With Alcohol on Driving-Related Skills.The international journal of neuropsychopharmacology · 2022Trial
- A randomized, placebo-controlled crossover trial of a decaffeinated energy drink shows no significant acute effect on mental energy.The American journal of clinical nutrition · 2020Trial
- Impact of High Volume Energy Drink Consumption on Electrocardiographic and Blood Pressure Parameters: A Randomized Trial.Journal of the American Heart Association · 2019Trial
- Renal Effects of Energy Drink Consumption: A Systematic Review and Meta-Analysis of Preclinical Studies.Toxics · 2026Review
- Chronic high consumption of energy drinks and cardiovascular risk in adolescents-results of the EDKAR-study.European journal of epidemiology · 2025Article
- Energy Drink Exposures and Trends in Children and Young Adults Reported to the National Poison Data System.Progress in pediatric cardiology · 2025Article
- Pediatric Exposures Associated with Caffeine Energy Products Reported to United States Poison Centers, 2011-2023.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2025Article
- No significant gender differences in driving-related skills following alcohol mixed with energy drinks during an experimental binge-drinking episode.Frontiers in pharmacology · 2025Article
- Common Questions and Misconceptions About Energy Drinks: What Does the Scientific Evidence Really Show?Nutrients · 2024Review
- Nutritional Risks of Heavy Metals in the Human Diet-Multi-Elemental Analysis of Energy Drinks.Nutrients · 2024Article
- Beneficial normalization of cardiac repolarization by carnitine in transgenic short QT syndrome type 1 rabbit models.Cardiovascular research · 2024Article
- Acute Cardiovascular Effects of Simultaneous Energy Drink and Alcohol Consumption in Young Adults: A Review of Case Reports.Pediatric reports · 2024Review
- Energy drink consumption and sleep parameters in college and university students: a national cross-sectional study.BMJ open · 2024Article
- International society of sports nutrition position stand: energy drinks and energy shots.Journal of the International Society of Sports Nutrition · 2023Review
- Energy Drinks and Adverse Health Events in Children and Adolescents: A Literature Review.Nutrients · 2023Review
- Experiences with energy drink consumption among Norwegian adolescents.Journal of nutritional science · 2023Article
- The Action of the Energy Drink on the Recovery Heart Rate is Independent of the Functional Capacity.Arquivos brasileiros de cardiologia · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCaffeine in doses <400 mg is typically not considered arrhythmogenic, but little is known about the additional ingredients in energy drinks. We evaluated the ECG and blood pressure (BP) effects of high-volume energy drink consumption compared with caffeine alone. METHODS AND
resultsThis was a randomized, double-blind, controlled, crossover study in 18 young, healthy volunteers. Participants consumed either 946 mL (32 ounces) of energy drink or caffeinated control drink, both of which contained 320 mg of caffeine, separated by a 6-day washout period. ECG, peripheral BP, and central BP measurements were obtained at baseline and 1, 2, 4, 6, and 24 hours post study drink consumption. The time-matched, baseline-adjusted changes were compared. The change in corrected QT interval from baseline in the energy drink arm was significantly higher than the caffeine arm at 2 hours (0.44±18.4 ms versus -10.4±14.8 ms, respectively;
conclusionsThe corrected QT interval and systolic BP were significantly higher post high-volume energy drink consumption when compared with caffeine alone. Larger clinical trials validating these findings and evaluation of noncaffeine ingredients within energy drinks are warranted. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02023723.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.