ArticleJMIR research protocols2017
Testing a Computerized Cognitive Training Protocol in Adults Aging With HIV-Associated Neurocognitive Disorders: Randomized Controlled Trial Rationale and Protocol.
Article in JMIR research protocols, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02758093 (An RCT of Speed of Processing Training in Middle-Aged and Older Adults With HIV), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An RCT of Speed of Processing Training in Middle-Aged and Older Adults With HIV
Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- A 2-Year Longitudinal Randomized Control Trial of Speed of Processing Cognitive Training in Aging Adults with HIV-Associated Neurocognitive Disorder: Results of the Think Fast Study.AIDS and behavior · 2024Trial
- A 2-year longitudinal randomized controlled trial examining the transfer of speed of processing training to secondary cognitive domains in middle-aged and older adults with HIV-associated neurocognitive disorder: Results of the think fast study.The Clinical neuropsychologist · 2024Trial
- Can Individualized-Targeted Computerized Cognitive Training Benefit Adults with HIV-Associated Neurocognitive Disorder? The Training on Purpose Study (TOPS).AIDS and behavior · 2021Trial
- Speed of processing training in middle-aged and older breast cancer survivors (SOAR): results of a randomized controlled pilot.Breast cancer research and treatment · 2018Trial
- Protocol for a Pilot Randomized Controlled Trial of a Resilience Intervention Adapted for Older People Living with HIV: Resilience Intervention for Successful Aging Enhancement (RISE+).Nursing (Auckland, N.Z.) · 2025Article
- Health Literacy Mediates Racial Differences in Cognitive Functioning among African American/Black and White People with and without HIV in the Deep South.Nursing (Auckland, N.Z.) · 2025Article
- Cognitive Intra-Individual Variability as an Outcome or Moderator of Speed of Processing Training in Aging Adults with HIV-Associated Neurocognitive Disorder: A Secondary Data Analysis of a 2-Year Longitudinal Randomized Clinical Trial.Archives of gerontology and geriatrics plus · 2024Article
- Driving habits, cognition, and health-related quality of life in middle-aged and older adults with HIV.Applied neuropsychology. Adult · 2023Article
- Cognitive Intra-individual Variability in HIV: an Integrative Review.Neuropsychology review · 2022Review
- Transportation Barriers and Health-Related Quality of Life in a Sample of Middle-Aged and Older Adults Living with HIV in the Deep South.AIDS and behavior · 2022Article
- A Conceptual View of Cognitive Intervention in Older Adults With and Without Cognitive Decline-A Systemic Review.Frontiers in aging · 2022Review
- Latinx with Type 2 Diabetes: Perceptions of Cognitive Health.Journal of immigrant and minority health · 2021Article
- Can computerized cognitive training reverse the diagnosis of HIV-associated neurocognitive disorder? A research protocol.Research in nursing & health · 2018Article
- Association between personality and cognitive performance in middle-aged and older adults with human immunodeficiency virus (HIV).Applied neuropsychology. AdultArticle
- Cardiometabolic Diseases and Quality-of-Life Outcomes in Adults With HIV in the Deep South: A Cross-sectional Study.The Journal of the Association of Nurses in AIDS Care : JANACArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHIV-associated neurocognitive disorders occur in nearly 50% of adults with HIV. Such disorders can interfere with everyday functioning such as driving and medication adherence. Therefore, cognitive interventions are needed to address such neurocognitive disorders as well as improve everyday functioning, especially as people age with HIV.
objectiveThis article reports and discusses the overall rationale and development of speed of processing training, a computerized Internet cognitive training program, to improve this specific neurocognitive ability as well as everyday functioning and quality of life in adults aging with HIV. Although this protocol has been shown to improve speed of processing, everyday functioning, and quality of life in healthy, community-dwelling older adults in the advanced cognitive training in vital elderly (ACTIVE) study, its efficacy in adults aging with HIV has not been established. Nevertheless, such a cognitive intervention is particularly germane as 52%-59% of adults with HIV experience HIV-associated neurocognitive disorders (HAND), and both the frequency and severity of such disorders may increase with advancing age.
methodsThe description of this longitudinal randomized controlled trial covers the following: (1) rationale for speed of processing training in this clinical population, (2) overview of overall study design, (3) eligibility criteria and HAND, (4) intervention dosage, (5) assessment battery, and (6) examination of biomarkers.
resultsThe project was funded in April 2016 and enrolment is on-going. The first results are expected to be submitted for publication in 2020.
conclusionsSimilar novel cognitive intervention approaches are suggested as they may be of value to those with HAND and may utilize similar features of this current randomized controlled trial (RCT) protocol to examine their therapeutic efficacy.
trial registrationClinicalTrials.gov NCT02758093; https://clinicaltrials.gov/ct2/show/NCT02758093 (Archived by Webcite at http://www.webcitation.org/6p8C5fBCX).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.