ArticleChimia2017
Progress in the Optimization of 4(1
Article in Chimia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
Funding
Abstract
Malaria is one of the leading infectious diseases occurring mainly in tropical and subtropical areas. Although available antimalarial tools have reduced the number of fatalities, there is still an urgent need for the development of new and more efficacious treatments to cure and eradicate malaria especially due to emerging resistance to all antimalarial drugs. Research was initiated to revisit antimalarial compounds which were deemed unsuitable as a result of poor understanding of physicochemical properties and the optimization thereof. The 4(1H)-quinolones are a class of compounds with demonstrated activity against malaria parasites. Recent optimization of the long-known core led to two highly promising compounds, i.e. P4Q-391 and ELQ-300, with great selective activity against all stages of the parasite's life cycle and good physicochemical properties. In this paper, we discuss the key steps on the way to these compounds, which fuel hope to find a suitable treatment for the prevention, cure and eradication of malaria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.