ArticleParasites & vectors2017
Mining a differential sialotranscriptome of Rhipicephalus microplus guides antigen discovery to formulate a vaccine that reduces tick infestations.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Immunoprotection Provided by Salivary and Intestinal Protein-Based Antigens Against the Ixodid TickVaccines · 2025Article
- Overview of Recombinant Tick Vaccines and Perspectives on the Use of Plant-Made Vaccines to Control Ticks of Veterinary Importance.Vaccines · 2024Review
- Glycine rich proteins of ticks: more than a cement component.Parasitology · 2024Review
- Efficacy of recombinant enolase as a candidate vaccine against Haemaphysalis longicornis tick infestation in mice.Parasites, hosts and diseases · 2023Article
- Transcriptome Profiling ofBiomedicines · 2023Article
- Co-Immunization Efficacy of Recombinant Antigens againstPathogens (Basel, Switzerland) · 2023Article
- Recent Advances in Tick Antigen Discovery and Anti-Tick Vaccine Development.International journal of molecular sciences · 2023Review
- Tick Vaccines and Concealed versus Exposed Antigens.Pathogens (Basel, Switzerland) · 2023Article
- Tick Salivary Kunitz-Type Inhibitors: Targeting Host Hemostasis and Immunity to Mediate Successful Blood Feeding.International journal of molecular sciences · 2023Review
- A proteomics informed by transcriptomics insight into the proteome of Ornithodoros erraticus adult tick saliva.Parasites & vectors · 2022Article
- Host Immune Responses to Salivary Components - A Critical Facet of Tick-Host Interactions.Frontiers in cellular and infection microbiology · 2022Review
- A Review of Australian Tick Vaccine Research.Vaccines · 2021Review
- Vertebrate Responses against Arthropod Salivary Proteins and Their Therapeutic Potential.Vaccines · 2021Review
- Probing theBiomedicines · 2021Article
- RNA-seq analysis and gene expression dynamics in the salivary glands of the argasid tick Ornithodoros erraticus along the trophogonic cycle.Parasites & vectors · 2021Article
- Repeat tick exposure elicits distinct immune responses in guinea pigs and mice.Ticks and tick-borne diseases · 2020Article
- A physiologic overview of the organ-specific transcriptome of the cattle tick Rhipicephalus microplus.Scientific reports · 2020Article
- Cocktail Anti-Tick Vaccines: The Unforeseen Constraints and Approaches toward Enhanced Efficacies.Vaccines · 2020Review
- Rhipicephalus microplus serpins interfere with host immune responses by specifically modulating mast cells and lymphocytes.Ticks and tick-borne diseases · 2020Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundTicks cause massive damage to livestock and vaccines are one sustainable substitute for the acaricides currently heavily used to control infestations. To guide antigen discovery for a vaccine that targets the gamut of parasitic strategies mediated by tick saliva and enables immunological memory, we exploited a transcriptome constructed from salivary glands from all stages of Rhipicephalus microplus ticks feeding on genetically tick-resistant and susceptible bovines.
resultsDifferent levels of host anti-tick immunity affected gene expression in tick salivary glands; we thus selected four proteins encoded by genes weakly expressed in ticks attempting to feed on resistant hosts or otherwise abundantly expressed in ticks fed on susceptible hosts; these sialoproteins mediate four functions of parasitism deployed by male ticks and that do not induce antibodies in naturally infected, susceptible bovines. We then evaluated in tick-susceptible heifers an alum-adjuvanted vaccine formulated with recombinant proteins. Parasite performance (i.e. weight and numbers of females finishing their parasitic cycle) and titres of antigen-specific antibodies were significantly reduced or increased, respectively, in vaccinated versus control heifers, conferring an efficacy of 73.2%; two of the antigens were strong immunogens, rich in predicted T-cell epitopes and challenge infestations boosted antibody responses against them.
conclusionMining sialotranscriptomes guided by the immunity of tick-resistant hosts selected important targets and infestations boosted immune memory against salivary antigens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.