ArticleCardiovascular diabetology2017
Retinal vessel diameters and reactivity in diabetes mellitus and/or cardiovascular disease.
Article in Cardiovascular diabetology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Benefits of dark chocolate intake on retinal vessels functionality: a randomized, blind, crossover clinical trial.Scientific reports · 2024Trial
- Quantifying Lateral Pulsation in Retinal Vessels Within the Optic Disc.Translational vision science & technology · 2026Article
- Repeatability of retinal vessel flicker responses in healthy individuals.Acta ophthalmologica · 2026Article
- Endothelial dysfunction in the kidney transplant population: Current evidence and management strategies.World journal of transplantation · 2025Review
- Retinal Vessel Analysis and Microvascular Abnormalities in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms.Journal of clinical medicine · 2024Article
- Peripheral retinal vessel whitening in patients with diabetes mellitus.Scientific reports · 2023Article
- Editorial: Functional assessments of the ocular circulation.Frontiers in medicine · 2023Article
- Ophthalmic artery changes in type 2 diabetes with and without acute coronary syndrome.Journal of translational medicine · 2022Article
- A stronger association of diabetes mellitus with impaired hyperaemia using a novel ECG-gated device compared with peripheral arterial tonometry.International ophthalmology · 2022Article
- A Deep Learning Network for Classifying Arteries and Veins in Montaged Widefield OCT Angiograms.Ophthalmology science · 2022Article
- E-Selectin Is Associated with Daytime and 24-Hour Diastolic Blood Pressure Variability in Type 2 Diabetes.Biomedicines · 2022Article
- Long-Term Oral Administration of Salidroside Alleviates Diabetic Retinopathy in db/db Mice.Frontiers in endocrinology · 2022Article
- A novel multiple subdivision-based algorithm for quantitative assessment of retinal vascular tortuosity.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Retinal vessel diameters, flicker-induced retinal vasodilation and retinal oxygen saturation in high- and low-risk pregnancy.Acta ophthalmologica · 2021Article
- Comparison of retinal vessel diameter measurements from swept-source OCT angiography and adaptive optics ophthalmoscope.The British journal of ophthalmology · 2021Article
- VasoMetrics: unbiased spatiotemporal analysis of microvascular diameter in multi-photon imaging applications.Quantitative imaging in medicine and surgery · 2021Article
- Non-invasive Assessment of Neurovascular Coupling After Aneurysmal Subarachnoid Hemorrhage: A Prospective Observational Trial Using Retinal Vessel Analysis.Frontiers in neurology · 2021Article
- Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program.Scientific reports · 2020Observational
- The Eyes.Circulation research · 2019Article
- Optical coherence tomography angiography in cardiovascular disease.Progress in cardiovascular diseasesReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRetinal vessel calibre and vascular dilation/constriction in response to flicker light provocation may provide a measure distinguishing patients suffering from diabetes mellitus and/or cardiovascular disease.
methodsOne hundred and sixteen age and sex matched patients with diabetes mellitus (DM), cardiovascular disease (CVD) and both DM and CVD (DM + CVD) underwent systemic and intraocular pressure measurements. Retinal vessel calibres were assessed using a validated computer-based program to compute central retinal artery and vein equivalents (CRVE) from monochromatic retinal images. Vessel dilation and constriction responses to flicker light provocation were assessed by continuous retinal vessel diameter recordings. Plasma endothelial markers von Willebrand factor (vWf) and soluble E selectin (sEsel) were measured by ELISA.
resultsRetinal vessel calibres were comparable across groups but CRVE correlated significantly with disease duration in DM patients (r = 0.57, p < 0.001). Patients suffering DM only exhibited reduced arterial vasomotion at rest and reduced arterial constriction following flicker light induced vessel dilation compared to patients with CVD and those suffering both CVD + DM (p = 0.030). Patients suffering from CVD + DM exhibited significant differences between each flicker cycle in regards to arterial maximum constriction (p = 0.006) and time needed to reach arterial maximum dilation (p = 0.004), whereas the other two groups did not show such inconsistencies between individual flicker cycles. vWf was raised in CVD + DM compared to the other two groups (p ≤ 0.02), whilst sEsel was raised in CVD + DM compared to DM alone (p = 0.044).
conclusionsDynamic retinal vascular calibres as obtained by continuous diameter measurements using flicker light provocation can reveal subtle differences between groups suffering from CVD with and without DM. This difference in reaction pattern and lack of arterial constriction in DM may provide a suitable marker to monitor progression.
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