ArticleBMC genomics2017
Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 82 citations in OpenAlex.
- Epigenetic and metabolic reprogramming of innate immune cells establishes immunological memory in the Schistosomiasis vector snail Biomphalaria glabrata.PLoS pathogens · 2026Article
- When Small Meets Smaller: Immune Modulation and Virulence Strategies in Insect-Bacteria Interactions.Insects · 2026Review
- Lack of Tolerance Development Following Oral Exposure Tosublethal Cry1 and Vip3Aa Proteins inInsects · 2026Article
- Gut bacteria induce heterologous immune priming in Rhodnius prolixus encompassing both humoral and cellular immune responses.PLoS pathogens · 2025Article
- Immune priming in the insect gut: a dynamic response revealed by ultrastructural and transcriptomic changes.BMC biology · 2025Article
- Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence.PLoS pathogens · 2025Article
- IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission.PLoS pathogens · 2024Article
- Epigenetic remodeling in insect immune memory.Frontiers in immunology · 2024Review
- Disentangling specific and unspecific components of innate immune memory in a copepod-tapeworm system.Frontiers in immunology · 2024Article
- Differential proteome profiling of bacterial culture supernatants reveals candidates for the induction of oral immune priming in the red flour beetle.Biology letters · 2023Article
- Efficient Oral Priming ofVaccines · 2022Article
- Serial passage in an insect host indicates genetic stability of the human probioticEvolution, medicine, and public health · 2022Article
- Pre-exposure toFrontiers in microbiology · 2022Article
- Oral Immune Priming Treatment Alters Microbiome Composition in the Red Flour BeetleFrontiers in microbiology · 2022Article
- Why do insects evolve immune priming? A search for crossroads.Developmental and comparative immunology · 2022Review
- Examining adaptive evolution of immune activity: opportunities provided by gastropods in the age of 'omics'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Transcriptome profiling of Lymnaea stagnalis (Gastropoda) for ecoimmunological research.BMC genomics · 2021Article
- Response Mechanisms of Invertebrates toMicrobiology and molecular biology reviews : MMBR · 2021Review
- Individuality in the Immune Repertoire and Induced Response of the SpongeFrontiers in immunology · 2021Article
- The nuclear and mitochondrial genomes of Frieseomelitta varia - a highly eusocial stingless bee (Meliponini) with a permanently sterile worker caste.BMC genomics · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe phenomenon of immune priming, i.e. enhanced protection following a secondary exposure to a pathogen, has now been demonstrated in a wide range of invertebrate species. Despite accumulating phenotypic evidence, knowledge of its mechanistic underpinnings is currently very limited. Here we used the system of the red flour beetle, Tribolium castaneum and the insect pathogen Bacillus thuringiensis (Bt) to further our molecular understanding of the oral immune priming phenomenon. We addressed how ingestion of bacterial cues (derived from spore supernatants) of an orally pathogenic and non-pathogenic Bt strain affects gene expression upon later challenge exposure, using a whole-transcriptome sequencing approach.
resultsWhereas gene expression of individuals primed with the orally non-pathogenic strain showed minor changes to controls, we found that priming with the pathogenic strain induced regulation of a large set of distinct genes, many of which are known immune candidates. Intriguingly, the immune repertoire activated upon priming and subsequent challenge qualitatively differed from the one mounted upon infection with Bt without previous priming. Moreover, a large subset of priming-specific genes showed an inverse regulation compared to their regulation upon challenge only.
conclusionsOur data demonstrate that gene expression upon infection is strongly affected by previous immune priming. We hypothesise that this shift in gene expression indicates activation of a more targeted and efficient response towards a previously encountered pathogen, in anticipation of potential secondary encounter.
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