Evidence map›Paper›PMID 28445803›Full record

ArticleBiomaterials2017

JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement.

Andrew K Capulli, Maximillian Y Emmert, Francesco S Pasqualini, Debora Kehl, Etem Caliskan, Johan U Lind, Sean P Sheehy, Sung Jin Park, Seungkuk Ahn, Benedikt Weber and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Review
  13. Nanomedicines for cardiovascular disease.Nature cardiovascular research · 2023
    Review
  14. Review
  15. The Application of Porous Scaffolds for Cardiovascular Tissues.Bioengineering (Basel, Switzerland) · 2023
    Review
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andrew K CapulliDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA.
Maximillian Y EmmertDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA; Institute for Regenerative Medicine (IREM), University of Zurich, Center for Therapy Development/GMP, 13 Moussonstrasse, Zurich, 8044, CH, Switzerland; Clinic for Cardiac Surgery, University Hospital Zurich, 100 Ramistrasse, Zurich, 8091, CH, Switzerland.
Francesco S PasqualiniDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA; Institute for Regenerative Medicine (IREM), University of Zurich, Center for Therapy Development/GMP, 13 Moussonstrasse, Zurich, 8044, CH, Switzerland.
Debora KehlInstitute for Regenerative Medicine (IREM), University of Zurich, Center for Therapy Development/GMP, 13 Moussonstrasse, Zurich, 8044, CH, Switzerland.
Etem CaliskanInstitute for Regenerative Medicine (IREM), University of Zurich, Center for Therapy Development/GMP, 13 Moussonstrasse, Zurich, 8044, CH, Switzerland; Clinic for Cardiac Surgery, University Hospital Zurich, 100 Ramistrasse, Zurich, 8091, CH, Switzerland.
Johan U LindDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA.
Sean P SheehyDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA.
Sung Jin ParkDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA.
Seungkuk AhnDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA.
Benedikt WeberDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA; Institute for Regenerative Medicine (IREM), University of Zurich, Center for Therapy Development/GMP, 13 Moussonstrasse, Zurich, 8044, CH, Switzerland.
Josue A GossDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA.
Simon P HoerstrupDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA; Institute for Regenerative Medicine (IREM), University of Zurich, Center for Therapy Development/GMP, 13 Moussonstrasse, Zurich, 8044, CH, Switzerland.
Kevin Kit ParkerDisease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA. Electronic address: kkparker@seas.harvard.edu.

Funding

Human Cardio-Pulmonary System on a ChipUH3TR000522 · NCATS · HARVARD MEDICAL SCHOOL · PI PARKER, KEVIN KIT · 2014 to 2016
$3.6M
NCATS NIH HHS UH3 TR000522
6 · The paper itself

Abstract

Tissue engineered scaffolds have emerged as a promising solution for heart valve replacement because of their potential for regeneration. However, traditional heart valve tissue engineering has relied on resource-intensive, cell-based manufacturing, which increases cost and hinders clinical translation. To overcome these limitations, in situ tissue engineering approaches aim to develop scaffold materials and manufacturing processes that elicit endogenous tissue remodeling and repair. Yet despite recent advances in synthetic materials manufacturing, there remains a lack of cell-free, automated approaches for rapidly producing biomimetic heart valve scaffolds. Here, we designed a jet spinning process for the rapid and automated fabrication of fibrous heart valve scaffolds. The composition, multiscale architecture, and mechanical properties of the scaffolds were tailored to mimic that of the native leaflet fibrosa and assembled into three dimensional, semilunar valve structures. We demonstrated controlled modulation of these scaffold parameters and show initial biocompatibility and functionality in vitro. Valves were minimally-invasively deployed via transapical access to the pulmonary valve position in an ovine model and shown to be functional for 15 h.

Indexed as

Biocompatible MaterialsTissue ScaffoldsAnimalsBiomimeticsHeart Valve ProsthesisHeart ValvesNanofibersSheepTissue EngineeringBiocompatible MaterialsBiohybridHeart valveNanofiberRapid manufactureRotary Jet SpinningTissue engineering

Identifiers

PMID28445803
PMCPMC5526340

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.