Evidence map›Paper›PMID 28445763›Full record

ArticleBiophysical journal2017

Myosin Rod Hypophosphorylation and CB Kinetics in Papillary Muscles from a TnC-A8V KI Mouse Model.

Masataka Kawai, Jamie R Johnston, Tarek Karam, Li Wang, Rakesh K Singh, Jose R Pinto

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Review
  9. Cardiomyocyte Dysfunction in Inherited Cardiomyopathies.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Article
  12. Structural and functional impact of troponin C-mediated CaJournal of molecular and cellular cardiology · 2018
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Masataka KawaiDepartments of Anatomy and Cell Biology, and Internal Medicine, College of Medicine, University of Iowa, Iowa City, Iowa. Electronic address: masataka-kawai@uiowa.edu.
Jamie R JohnstonDepartment of Biomedical Sciences, College of Medicine, The Florida State University, Tallahassee, Florida.
Tarek KaramDepartments of Anatomy and Cell Biology, and Internal Medicine, College of Medicine, University of Iowa, Iowa City, Iowa.
Li WangDepartments of Anatomy and Cell Biology, and Internal Medicine, College of Medicine, University of Iowa, Iowa City, Iowa; School of Nursing, Soochow University, Suzhou, Jiangsu, China.
Rakesh K SinghTranslational Science Laboratory, College of Medicine, The Florida State University, Tallahassee, Florida.
Jose R PintoDepartment of Biomedical Sciences, College of Medicine, The Florida State University, Tallahassee, Florida.
Florida State University · USUniversity of Iowa · US

Funding

Modulators of Cardiomyopathic DiseasesR01HL128683 · NHLBI · FLORIDA STATE UNIVERSITY · PI PINTO, JOSE RENATO · 2016 to 2020
$1.8M
The Role of Cardiomyopathic Troponin C Mutations in Skeletal and Cardiac Muscle CR00HL103840 · NHLBI · FLORIDA STATE UNIVERSITY · PI PINTO, JOSE RENATO · 2012 to 2014
$717k
The Role of Cardiomyopathic Troponin C Mutations in Skeletal and Cardiac Muscle CK99HL103840 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PINTO, JOSE RENATO · 2010 to 2011
$188k
NHLBI NIH HHS K99 HL103840NHLBI NIH HHS R00 HL103840NHLBI NIH HHS R01 HL128683
6 · The paper itself

Abstract

The cardiac troponin C (TnC)-A8V mutation is associated with hypertrophic and restrictive cardiomyopathy (HCM and RCM) in human and mice. The residue affected lies in the N-helix, a region known to affect Ca

Indexed as

Adenosine TriphosphateAnimalsCalciumCardiomyopathy, HypertrophicCations, DivalentChromatography, LiquidDisease Models, AnimalGene Knock-In TechniquesImmunoblottingKineticsMice, TransgenicMyofibrilsMyosin Heavy ChainsMyosin SubfragmentsPapillary MusclesPhosphorylationAdenosine TriphosphateCalciumCations, DivalentMyh6 protein, mouseMyosin Heavy ChainsMyosin SubfragmentsTroponin C

Identifiers

PMID28445763
PMCPMC5406373
OpenAlexW2607893310

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.