Evidence map›Paper›PMID 28445727›Full record

ArticleCell reports2017

Environmental Enrichment Induces Pericyte and IgA-Dependent Wound Repair and Lifespan Extension in a Colon Tumor Model.

Benjamin D Bice, Megan R Stephens, Stephanie J Georges, Ashlee R Venancio, Peter C Bermant, Annika V Warncke, Kajsa E Affolter, Julio R Hidalgo, Melinda L Angus-Hill

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Upregulation ofGut microbes · 2025
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  18. The non-invasive measurement of faecal immunoglobulin in African equids.International journal for parasitology. Parasites and wildlife · 2020
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Benjamin D BiceDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA.
Megan R StephensDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA.
Stephanie J GeorgesDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA.
Ashlee R VenancioDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA.
Peter C BermantDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA.
Annika V WarnckeDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA.
Kajsa E AffolterDepartment of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
Julio R HidalgoDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA.
Melinda L Angus-HillDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA. Electronic address: melinda.angus-hill@hci.utah.edu.
University of Utah · USHuntsman Cancer Institute · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
TCF/LEF function during intestinal maintenance and colon tumorigenesisP01CA073992 · NCI · UNIVERSITY OF UTAH · PI CAPECCHI, MARIO R · 1998 to 2014
$29.7M
Mouse Models of Sporadic Colorectal CancerK01CA128891 · NCI · UNIVERSITY OF UTAH · PI ANGUS-HILL, MELINDA · 2008 to 2012
$623k
NCI NIH HHS K01 CA128891NCI NIH HHS P01 CA073992NCI NIH HHS P30 CA042014
6 · The paper itself

Abstract

Environmental enrichment (EE) replicates mind-body therapy by providing complex housing to laboratory animals to improve their activity levels, behavior, and social interactions. Using a Tcf4

Indexed as

EnvironmentAdenomatous Polyposis Coli ProteinAlphaproteobacteriaAnimalsColonColonic NeoplasmsCytokinesDisease Models, AnimalFemaleImmunoglobulin AMaleMiceMicrobiotaNeovascularization, PhysiologicPericytesProteobacteriaAdenomatous Polyposis Coli Proteinadenomatous polyposis coli protein, mouseCytokinesImmunoglobulin AReceptors, Cytoplasmic and NuclearTcf4 protein, mouseTranscription Factor 4colon cancerenvironmental enrichmentIgAmicrobiotamind-body medicinenuclear hormone receptorspericyteswound repair

Identifiers

PMID28445727
PMCPMC5474344
OpenAlexW2607864152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.