Evidence map›Paper›PMID 28445469›Full record

ArticleNature2017

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Christopher Abbosh, Nicolai J Birkbak, Gareth A Wilson, Mariam Jamal-Hanjani, Tudor Constantin, Raheleh Salari, John Le Quesne, David A Moore, Selvaraju Veeriah, Rachel Rosenthal and 96 more

Erratum issued 11 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 11 registered trials, which are not on this map. Cited by 1,071 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,071citing papers in PubMed, 4 pooled it
56.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03838588 unknown statusnot on this mapstarted 2018, after this paper: background citation

Tracking Genomic Cancer Evolution in Patients for Stage IB,II and IIIA Non-small Cell Lung Cancer After Radical Resection: The Tracking Molecular Evolution for NSCLC (T-MENC) Study

TypeobservationalSponsorGeneplus-Beijing Co. Ltd.Ran2018 to 2021Enrolled200ConditionsLung Neoplasms, Lung Cancer, Nonsmall Cell Lung Cancer, Adenocarcinoma of Lung
NCT04752930 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Circulating Tumor DNA (ctDNA) as a Assisted Diagnosis, Early Intervention and Prognostic Marker for Peritoneal Metastases From Colorectal Cancer: A Prospective, Open-label, Randomized Controlled Study

TypeinterventionalSponsorSixth Affiliated Hospital, Sun Yat-sen UniversityRan2020 to 2025Enrolled138ConditionsColorectal Cancer, Peritoneal MetastasesArmsctDNA monitoring, Imageology
NCT04985266 phase2recruitingnot on this mapstarted 2022, after this paper: background citation

A Randomised Trial of Early Detection of Molecular Relapse With Circulating Tumour DNA Tracking and Treatment With Palbociclib Plus Fulvestrant Versus Standard Endocrine Therapy in Patients With ER Positive HER2 Negative Breast Cancer

TypeinterventionalSponsorRoyal Marsden NHS Foundation TrustRan2022 to 2030Enrolled1,100ConditionsER+ Breast Cancer, HER2-negative Breast CancerArmsPalbociclib 125Mg Tab, Fulvestrant injection, Tamoxifen, Letrozole, Exemestane
NCT05058183 narecruitingnot on this mapstarted 2023, after this paper: background citation

Safe De-escalation of Chemotherapy for Stage 1 Breast Cancer

TypeinterventionalSponsorRoyal Marsden NHS Foundation TrustRan2023 to 2028Enrolled400ConditionsBreast CancerArmsctDNA
NCT05167604 unknown statusnot on this mapstarted 2021, after this paper: background citation

Utility of ctDNA In Predicting Whether Giving Adjuvant Chemotherapy In Patients With Stage IB-IIA Resected Non-small Cell Lung Cancer: A Prospective Cohort Study

Typeobservational_patient_registrySponsorTang-Du HospitalRan2021 to 2024Enrolled150ConditionsCarcinoma, Non-Small-Cell Lung, Next-Generation Sequencing, Chemotherapy, Adjuvant, Neoplasm, ResidualArmsAdjuvants, Pharmaceutic
NCT05224596 unknown statusnot on this mapstarted 2021, after this paper: background citation

Gastric Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study

TypeobservationalSponsorShanghai Zhongshan HospitalRan2021 to 2022Enrolled498ConditionsCancerArmsBlood draw and blood-based biomarkers analyses
NCT05408897 recruitingnot on this mapstarted 2022, after this paper: background citation

Prediction of Postoperative Treatment Efficacy and Recurrence Risk of High-risk GIST Based on Minimal Residual Disease Detected by Liquid Biopsy

TypeobservationalSponsorPeking University People's HospitalRan2022 to 2028Enrolled45ConditionsGastrointestinal Stromal Tumors, Minimal Residual DiseaseArmsliquid biopsy
NCT05495685 unknown statusnot on this mapstarted 2022, after this paper: background citation

Pancreatic Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study

TypeobservationalSponsorChanghai HospitalRan2022 to 2024Enrolled450ConditionsCancer
NCT05556603 recruitingnot on this mapstarted 2022, after this paper: background citation

Pancreatic Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study

TypeobservationalSponsorRuijin HospitalRan2022 to 2029Enrolled7,062ConditionsCancer
NCT06358222 recruitingnot on this mapstarted 2023, after this paper: background citation

Predicting NSCLC Lymph Node Metastasis: Integrating ctDNA Mutation/ Methylation Profiling With PET-CT Scan: The LUNon-invasive Study

TypeobservationalSponsorShanghai Chest HospitalRan2023 to 2027Enrolled200ConditionsCarcinoma, Non-small Cell Lung CancerArmsBlood ctDNA + methylation + PET-CT and Postoperative pathology, MRD+ methylation (or combined with PET-CT) and Invasive mediastinoscopy /EBUS-TBNA, Intraoperative lymph node dissection
NCT07057102 recruitingnot on this mapstarted 2025, after this paper: background citation

Applications of Multiple Omics Sequencing Technologies in Predicting the Efficacy and Monitoring the Recurrence of Non-Small Cell Lung Cancer: A Prospective, Non-Interventional Study

Typeobservational_patient_registrySponsorCancer Institute and Hospital, Chinese Academy of Medical SciencesRan2025 to 2027Enrolled40ConditionsNon Small Cell Lung Cancer
3 · Its place in the literature

Who cites it

1,071 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,846 citations in OpenAlex.

  1. Pooled it
  2. Prognostic value of postoperative circulating tumor DNA for recurrence-free survival in resected non-small cell lung cancer: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Detection of Circulating Tumor DNA Using a Tissue-Free Epigenomic Assay Is a Highly Prognostic Biomarker in Early-Stage Triple-Negative Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Trial
  8. Trial
  9. Review
  10. Article
  11. Article
  12. Value and research advances of ctDNA in perioperative therapy for non-small cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

1,011 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

106 authors at 20 institutions in 6 countries.

Christopher AbboshCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Nicolai J BirkbakCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Gareth A WilsonCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Mariam Jamal-HanjaniCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Tudor ConstantinNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
Raheleh SalariNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
John Le QuesneCancer Studies, University of Leicester, Leicester LE2 7LX, UK.
David A MooreCancer Studies, University of Leicester, Leicester LE2 7LX, UK.
Selvaraju VeeriahCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Rachel RosenthalCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Teresa MarafiotiCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Eser KirkizlarNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
Thomas B K WatkinsCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Nicholas McGranahanCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Sophia WardCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Luke MartinsonCancer Studies, University of Leicester, Leicester LE2 7LX, UK.
Joan RileyCancer Studies, University of Leicester, Leicester LE2 7LX, UK.
Francesco FraioliDepartment of Nuclear Medicine, University College London Hospitals, 235 Euston Road, Fitzrovia, London, NW1 2BU, UK.
Maise Al BakirTranslational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Eva GrönroosTranslational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Francisco ZambranaCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Raymondo EndozoDepartment of Nuclear Medicine, University College London Hospitals, 235 Euston Road, Fitzrovia, London, NW1 2BU, UK.
Wenya Linda BiBrigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Fiona M FennessyBrigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Nicole SponerNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
Diana JohnsonCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Joanne LaycockCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Seema ShafiCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Justyna Czyzewska-KhanCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Andrew RowanTranslational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Tim ChambersTranslational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Nik MatthewsAdvanced Sequencing Facility, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Samra TurajlicTranslational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Crispin HileyCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Siow Ming LeeCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Martin D ForsterCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Tanya AhmadDepartment of Oncology, University College London Hospitals, 250 Euston Road, London NW1 2BU, UK.
Mary FalzonDepartment of Pathology, University College London Hospitals, 21 University Street, London WC1 6JJ, UK.
Elaine BorgDepartment of Pathology, University College London Hospitals, 21 University Street, London WC1 6JJ, UK.
David LawrenceDepartment of Cardiothoracic Surgery, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK.
Martin HaywardDepartment of Cardiothoracic Surgery, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK.
Shyam KolvekarDepartment of Cardiothoracic Surgery, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK.
Nikolaos PanagiotopoulosDepartment of Cardiothoracic Surgery, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK.
Sam M JanesCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Ricky ThakrarDepartment of Respiratory Medicine, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK.
Asia AhmedDepartment of Radiology, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK.
Fiona BlackhallInstitute of Cancer Studies, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Yvonne SummersThe Christie Hospital, Manchester M20 4BX, UK.
Dina HafezNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
Ashwini NaikNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
Apratim GangulyNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
Stephanie KarehtNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
Rajesh ShahDepartment of Cardiothoracic Surgery, University Hospital South Manchester, Manchester M23 9LT, UK.
Leena JosephDepartment of Pathology, University Hospital South Manchester, Manchester M23 9LT, UK.
Anne Marie QuinnDepartment of Pathology, University Hospital South Manchester, Manchester M23 9LT, UK.
Phil A CrosbieNorth West Lung Centre, University Hospital South Manchester, Manchester M23 9LT, UK.
Babu NaiduDepartment of Thoracic Surgery, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.
Gary MiddletonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
Gerald LangmanDepartment of Cellular Pathology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.
Simon TrotterDepartment of Cellular Pathology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.
Marianne NicolsonDepartment of Medical Oncology, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.
Hardy RemmenDepartment of Cardiothoracic Surgery, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZD, UK.
Keith KerrDepartment of Pathology, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZD, UK.
Mahendran ChettyDepartment of Respiratory Medicine, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.
Lesley GomersallDepartment of Radiology, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.
Dean A FennellCancer Studies, University of Leicester, Leicester LE2 7LX, UK.
Apostolos NakasDepartment of Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK.
Sridhar RathinamDepartment of Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK.
Girija AnandDepartment of Radiotherapy, North Middlesex University Hospital, London N18 1QX, UK.
Sajid KhanDepartment of Respiratory Medicine, Royal Free Hospital, Pond Street, London NW3 2QG, UK.
Peter RussellDepartment of Respiratory Medicine, The Princess Alexandra Hospital, Hamstel Road, Harlow CM20 1QX, UK.
Veni EzhilDepartment of Clinical Oncology, St.Luke's Cancer Centre, Royal Surrey County Hospital, Guildford GU2 7XX, UK.
Babikir IsmailDepartment of Pathology, Ashford and St. Peter's Hospital, Guildford Road, Chertsey, Surrey KT16 0PZ, UK.
Melanie Irvin-SellersDepartment of Respiratory Medicine, Ashford and St. Peter's Hospital, Guildford Road, Chertsey, Surrey KT16 0PZ, UK.
Vineet PrakashDepartment of Radiology, Ashford and St. Peter's Hospital, Guildford Road, Chertsey, Surrey KT16 0PZ, UK.
Jason F LesterDepartment of Clinical Oncology, Velindre Hospital, Cardiff CF14 2TL, UK.
Malgorzata KornaszewskaDepartment of Cardiothoracic Surgery, University Hospital of Wales, Cardiff CF14 4XW, UK.
Richard AttanoosDepartment of Cellular Pathology, University Hospital of Wales and Cardiff University, Heath Park, Cardiff, UK.
Haydn AdamsDepartment of Radiology, University Hospital Llandough, Cardiff CF64 2XX, UK.
Helen DaviesDepartment of Respiratory Medicine, University Hospital Llandough, Cardiff CF64 2XX, UK.
Dahmane OukrifCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Ayse U AkarcaCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
John A HartleyUniversity College London Experimental Cancer Medicine Centre GCLP Facility, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Helen L LoweUniversity College London Experimental Cancer Medicine Centre GCLP Facility, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Sara LockDepartment of Respiratory Medicine, The Whittington Hospital NHS Trust, London, N19 5NF, UK.
Natasha IlesUniversity College London, Cancer Research UK and UCL Cancer Trials Centre, London W1T 4TJ, UK.
Harriet BellUniversity College London, Cancer Research UK and UCL Cancer Trials Centre, London W1T 4TJ, UK.
Yenting NgaiUniversity College London, Cancer Research UK and UCL Cancer Trials Centre, London W1T 4TJ, UK.
Greg ElgarTranslational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Zoltan SzallasiCentre for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark.
Roland F SchwarzBerlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Javier HerreroBill Lyons Informatics Centre, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Aengus StewartDepartment of Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Sergio A QuezadaCancer Immunology Unit, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Karl S PeggsCancer Immunology Unit, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
Peter Van LooCancer Genomics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Caroline DiveCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
C Jimmy LinNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
Matthew RabinowitzNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
Hugo J W L AertsBrigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Allan HackshawUniversity College London, Cancer Research UK and UCL Cancer Trials Centre, London W1T 4TJ, UK.
Jacqui A ShawCancer Studies, University of Leicester, Leicester LE2 7LX, UK.
Bernhard G ZimmermannNatera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
TRACERx consortium
PEACE consortium
Charles SwantonCancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
CRUK Lung Cancer Centre of Excellence · GBThe Francis Crick Institute · GBUniversity College Hospital · GBNatera (United States) · USUniversity of Leicester · GBAberdeen Royal Infirmary · GBCancer Research UK · GBBrigham and Women's Hospital · USWithington Community Hospital · GBAshford and St Peter's Hospitals NHS Foundation Trust · GBGlenfield Hospital · GBHeartlands Hospital · GBUniversity Hospital Llandough · GBUniversity Hospital of Wales · GBCancer Research UK Manchester Institute · GBInstitute of Cancer Research · GBMax Delbrück Center · DENorth Middlesex Hospital · GBPrincess Alexandra Hospital NHS Trust · GBRoyal Surrey County Hospital · GB

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Cancer Research UK 15951Cancer Research UK 15954Cancer Research UK 17786Cancer Research UK 17891Cancer Research UK 18176Cancer Research UK 18892Cancer Research UK 19278Cancer Research UK 19310Cancer Research UK 20265Cancer Research UK 20274Cancer Research UK 20275Cancer Research UK 20276Cancer Research UK 20465Cancer Research UK 20466Cancer Research UK 20613Cancer Research UK 21999Cancer Research UK 22246Cancer Research UK 22795Cancer Research UK 23896Medical Research Council G108/596Medical Research Council MC_UP_1203/1NCATS NIH HHS UL1 TR001863Wellcome Trust FC001169Wellcome Trust FC001202
6 · The paper itself

Abstract

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.

Indexed as

Evolution, MolecularBiopsyCarcinoma, Non-Small-Cell LungCell LineageCell TrackingClone CellsDisease ProgressionDNA Mutational AnalysisDNA, NeoplasmDrug Resistance, NeoplasmEarly Detection of CancerHumansLimit of DetectionLung NeoplasmsMultiplex Polymerase Chain ReactionNeoplasm MetastasisDNA, Neoplasm

Identifiers

PMID28445469
PMCPMC5812436
OpenAlexW2608738563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.