ArticleNature2017
The mitochondrial Na
Abstract read
In one paragraph
Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 239 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
239citing papers in PubMed, 1 pooled it
17.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
239 citing papers in PubMed, 1 synthesis or guideline pooled it, 381 citations in OpenAlex.
- Comprehensive analysis of regulated cell death pathways: intrinsic disorder, protein-protein interactions, and cross-pathway communication.Apoptosis : an international journal on programmed cell death · 2025Pooled it
- Mitochondrial heterogeneity across cardiac cell types in heart failure with preserved ejection fraction.Redox biology · 2026Review
- Sonogenetics Nanomedicine Activates the cGAS-STING Pathway for Immunotherapy of Triple-Negative Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Experimental workflows for the accurate identification of mitochondrial redox events.Redox biology · 2026Review
- Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia-reperfusion injury.The Journal of physiology · 2026Review
- A ratiometric fluorescent reporter of mitochondrial sodium.Nature chemical biology · 2026Article
- Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.The EMBO journal · 2026Article
- The two faces of mitochondrial CaJournal of physiology and biochemistry · 2026Review
- Review
- Stem Cell-Derived Exosomes Regulate Mitochondrial Function: A Novel Strategy for Parkinson's Disease Therapy.Molecular neurobiology · 2026Review
- Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review).International journal of molecular medicine · 2026Review
- MICU proteins facilitate calcium-dependent mitochondrial metabolon formation to regulate cellular energetics independently of MCU.Nature metabolism · 2026Article
- Activation of TPC2 amplifies lysosome-mitochondria calcium transfer to regulate energetic stress responses.bioRxiv : the preprint server for biology · 2026Article
- Mitochondrial Calcium Dysregulation and Targeted Therapies in Heart Failure.Reviews in cardiovascular medicine · 2026Review
- Prussian blue nanoparticles targeting multiple PANoptosome-mediated PANoptosis for myocardial ischemia-reperfusion injury therapy.Nature communications · 2026Article
- Disrupted SR-Mitochondria Coupling Drives Ischemia-Reperfusion Vulnerability in the Middle-Aged Rat Heart.Biomedicines · 2026Article
- Decoding mitochondrial signaling: neutrophil-tumor cell crosstalk in orchestrating cancer progression.Journal of translational medicine · 2026Review
- Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish.Communications biology · 2026Article
- Sodium disrupts mitochondrial energy metabolism to execute NECSO.Nature communications · 2025Article
- Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer's disease.Journal of advanced research · 2025Review
179 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 1 country.
Timothy S LuongoCenter for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Jonathan P LambertCenter for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Polina GrossCardiovascular Research Center, Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Mary NwokediCenter for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Alyssa A LombardiCenter for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Santhanam ShanmughapriyaCenter for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
April C CarpenterDepartment of Health and Exercise Physiology, Ursinus College, Collegeville, Pennsylvania 19426, USA.
Devin KolmetzkyCenter for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Erhe GaoCenter for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Jop H van BerloDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Emily J TsaiDivision of Cardiology, Department of Medicine, College of Physicians &Surgeons, Columbia University, New York, New York 10032, USA.
Jeffery D MolkentinDepartment of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, Cincinnati, Ohio 45229, USA.
Xiongwen ChenCardiovascular Research Center, Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Muniswamy MadeshCenter for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Steven R HouserCardiovascular Research Center, Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
John W ElrodCenter for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Temple University · USCincinnati Children's Hospital Medical Center · USColumbia University · USUniversity of Minnesota · USUrsinus College · US
Funding
Project 3 Dysregulation of metabolic communication of oligodendrocytes and neurons by cocaine and TatP01DA037830 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI LANGFORD, DIANNE TERESA · 2015 to 2019
$7.4MMolecular examination of mitochondrial calcium controlR01HL132831 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BERS, DONALD M, MOLKENTIN, JEFFERY D · 2016 to 2024
$5.9MCoordination of Pathophysiologic Endothelial Cell Signaling by ROSR01HL086699 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2008 to 2018
$4.3MSpectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3MMechanisms of mitochondrial calcium exchange in heart failureR01HL123966 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2014 to 2018
$2.3MStrategic activation of endogenous c-kit+ progenitor cells for cardiac regenerationR01HL130072 · NHLBI · UNIVERSITY OF MINNESOTA · PI VAN BERLO, JOHANNES (JOP) · 2016 to 2020
$1.9MNovel Molecular Mechanisms of Programmed NecrosisR01HL136954 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2017 to 2020
$1.6MFunctional Implications of Caveolae-Localized Myocardial sGC in Heart FailureK08HL109159 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI TSAI, EMILY J · 2012 to 2016
$703kNHLBI NIH HHS K08 HL109159NHLBI NIH HHS R01 HL086699NHLBI NIH HHS R01 HL123966NHLBI NIH HHS R01 HL130072NHLBI NIH HHS R01 HL132831NHLBI NIH HHS R01 HL136954NIDA NIH HHS P01 DA037830NIGMS NIH HHS R01 GM109882
Abstract
Mitochondrial calcium (
Indexed as
HomeostasisAnimalsCalciumCell SurvivalDeath, SuddenFemaleGene DeletionHeart FailureHeLa CellsHumansMaleMiceMitochondriaMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMyocardiumCalciumMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreSlc8b1protein, mouseSodium-Calcium ExchangerSuperoxidesTamoxifen
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.