ArticleOrganic letters2017
Synergistic Visible-Light Photoredox/Nickel-Catalyzed Synthesis of Aliphatic Ketones via N-C Cleavage of Imides.
Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 122 citations in OpenAlex.
- Recent advances in the cleavage of non-activated amides.Beilstein journal of organic chemistry · 2026Review
- Mechanistic insights on C(acyl)-N functionalisation mediated by late transition metals.Dalton transactions (Cambridge, England : 2003) · 2024Review
- Amide N-C Bond Activation: A Graphical Overview of Acyl and Decarbonylative Coupling.SynOpen (2017) · 2023Article
- Visible-light-induced nickel-catalyzed α-hydroxytrifluoroethylation of alkyl carboxylic acids: Access to trifluoromethyl alkyl acyloins.Beilstein journal of organic chemistry · 2023Article
- Direct Dehydrogenative Access to Unsymmetrical Phenones.Angewandte Chemie (International ed. in English) · 2022Article
- Synthesis of Cyclohexanones by a Tandem Photocatalyzed Annulation.Journal of the American Chemical Society · 2022Article
- Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis.Chemical reviews · 2022Review
- Nickel-Mediated Photoreductive Cross Coupling of Carboxylic Acid Derivatives for Ketone Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Article
- Benzylic C(spChemical science · 2021Article
- Activation of C-O and C-N Bonds Using Non-Precious-Metal Catalysis.ACS catalysis · 2020Article
- Generation of Alkyl Radicals: From the Tyranny of Tin to the Photon Democracy.Chemical reviews · 2020Article
- Stereochemistry of Transition Metal Complexes Controlled by the Metallo-Anomeric Effect.Journal of the American Chemical Society · 2020Article
- Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids.Nature communications · 2020Article
- Ketone Synthesis from Benzyldiboronates and Esters: Leveraging α-Boryl Carbanions for Carbon-Carbon Bond Formation.Journal of the American Chemical Society · 2020Article
- Ni-Catalyzed Suzuki-Miyaura Cross-Coupling of Aliphatic Amides on the Benchtop.Organic letters · 2020Article
- Alkyl Carbon-Carbon Bond Formation by Nickel/Photoredox Cross-Coupling.Angewandte Chemie (International ed. in English) · 2019Review
- Photoredox/Nickel-Catalyzed Single-Electron Tsuji-Trost Reaction: Development and Mechanistic Insights.Angewandte Chemie (International ed. in English) · 2018Article
- Computational Study of Mechanism and Thermodynamics of Ni/IPr-Catalyzed Amidation of Esters.Molecules (Basel, Switzerland) · 2018Article
- Nickel-Catalyzed Suzuki-Miyaura Coupling of Aliphatic Amides.ACS catalysis · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
An electrophilic, imide-based, visible-light-promoted photoredox/Ni-catalyzed cross-coupling reaction for the synthesis of aliphatic ketones has been developed. This protocol proceeds through N-C(O) bond activation, made possible through the lower activation energy for metal insertion into this bond due to delocalization of the lone pair of electrons on the nitrogen by electron-withdrawing groups. The operationally simple and mild cross-coupling reaction is performed at ambient temperature and exhibits tolerance for a variety of functional groups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.