ArticleClinical cardiology2017
Correlation between genetic polymorphisms within the MAPK1/HIF-1/HO-1 signaling pathway and risk or prognosis of perimenopausal coronary artery disease.
Article in Clinical cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction.Human genomics · 2019Pooled it
- Integrative functional analysis of super enhancer SNPs for coronary artery disease.Journal of human genetics · 2018Pooled it
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- Hypoxia-Inducible Factor 1-Alpha Gene Polymorphisms Impact Risk of Severespectrum Hypertensive Disorders of Pregnancy: A Case-Control Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Super-Enhancers and Their Parts: From Prediction Efforts to Pathognomonic Status.International journal of molecular sciences · 2024Review
- The Modulation of Nrf-2/HO-1 Signaling Axis byPlants (Basel, Switzerland) · 2021Article
- Deciphering key genes in cardio-renal syndrome using network analysis.Bioinformation · 2021Article
- Comparative study of gene expression profiles rooted in acute myocardial infarction and ischemic/reperfusion rat models.American journal of cardiovascular disease · 2020Article
- Article
- Phosphorylated proteomics analysis of human coronary artery endothelial cells stimulated by Kawasaki disease patients serum.BMC cardiovascular disorders · 2019Article
- Peripheral-blood gene expression profiling studies for coronary artery disease and its severity in Xinjiang population in China.Lipids in health and disease · 2018Article
- Correlation between genetic polymorphisms within the MAPK1/HIF-1/HO-1 signaling pathway and risk or prognosis of perimenopausal coronary artery disease.Clinical cardiology · 2017Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundMitogen-activated protein kinase-1 (MAPK1), as well as its downstream factors of hypoxia-inducible factor-1 (HIF-1) and heme oxygenase-1 (HO-1), have been documented to be involved in modulating development of coronary artery disease (CAD). HYPOTHESIS: Genetic mutations within the MAPK1/HIF-1/HO-1 signaling pathway could alter the risk of perimenopausal CAD in Chinese patients.
methodsPeripheral blood samples were gathered from 589 CAD patients and 860 healthy controls, and 12 potential single-nucleotide polymorphisms (SNPs) were obtained from HapMap database and previously published studies. Genotyping of SNPs was implemented with the TaqMan SNP Genotyping Assays. Odds ratios (OR) and 95% confidence intervals (CI) were utilized to evaluate the correlations between SNPs and CAD risk.
resultsRegarding MAPK1 , rs6928 (OR: 1.71, 95% CI: 1.47-1.98, P < 0.05), rs9340 (OR: 0.85, 95% CI: 0.73-0.99, P < 0.05), and rs11913721 (OR: 0.70, 95% CI: 0.52-0.95, P < 0.05) were remarkably associated with susceptibility to perimenopausal CAD. Of these, rs9340 and rs11913721 were also regarded as protective factors for perimenopausal CAD patients. Moreover, results of HIF-1 indicated noticeable correlations between combined SNPs of rs1087314 and rs2057482 and risk of perimenopausal CAD (OR: 1.24, 95% CI: 1.01-1.53, P < 0.05; and OR: 0.71, 95% CI: 0.55-0.91, P < 0.05, respectively). Nonetheless, rs2071746 in HO-1 was found to be only associated with perimenopausal CAD risk (OR: 0.67, 95% CI: 0.58-0.78, P < 0.05).
conclusionsThe genetic mutations within MAPK1 (rs6928, rs9340, rs11913721), HIF-1 (rs1087314, rs2057482), and HO-1 (rs2071746) could alter susceptibility to perimenopausal CAD in this Chinese population.
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