Evidence map›Paper›PMID 28444741›Full record

ArticleBritish journal of haematology2018

Haem augments and iron chelation decreases toll-like receptor 4 mediated inflammation in monocytes from sickle cell patients.

Pradeep K Dagur, J Philip McCoy, James Nichols, Laura Mendelsohn, Catherine Seamon, Gregory J Kato, Eduard J van Beers

Open access · bronzeAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Pradeep K DagurHematology Branch and Flow Cytometry Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
J Philip McCoyHematology Branch and Flow Cytometry Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
James NicholsHematology Branch and Flow Cytometry Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Laura MendelsohnHematology Branch and Flow Cytometry Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Catherine SeamonHematology Branch and Flow Cytometry Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Gregory J KatoDivision of Hematology-Oncology and Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-4465-3217
Eduard J van BeersVan Creveldkliniek, Centre for Benign Haematology, University Medical Centre Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-3934-7189
National Institutes of Health · USUniversity Medical Center Utrecht · NLUniversity of Pittsburgh · US

Funding

Flow Cytometry Core FacilityZICHL005905 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DAGUR, PRADEEP · 2009 to 2025
$32.3M
Blood Studies of Endothelial Function and Systemic InflammationZIAHL006013 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KATO, GREGORY · 2009 to 2013
$680k
Intramural NIH HHS ZIA HL006013NULL ZIA HL006013-05
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Sickle CellHumansInflammationIron Chelating AgentsLipopolysaccharidesMonocytesToll-Like Receptor 4Iron Chelating AgentsLipopolysaccharidesTLR4 protein, humanToll-Like Receptor 4inflammationiron metabolismmonocytessickle cell diseasetoll-like receptor 4

Identifiers

PMID28444741
PMCPMC5869174
OpenAlexW2608296304

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.