ArticleBritish journal of pharmacology2017
Factors influencing biased agonism in recombinant cells expressing the human α
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- αPharmaceuticals (Basel, Switzerland) · 2025Review
- Functional characterization of the αFrontiers in pharmacology · 2025Article
- Adrenoceptor Desensitization: Current Understanding of Mechanisms.Pharmacological reviews · 2024Review
- Adrenoceptors: Receptors, Ligands and Their Clinical Uses, Molecular Pharmacology and Assays.Handbook of experimental pharmacology · 2024Review
- αInternational journal of molecular sciences · 2023Review
- Characterization of a novel positive allosteric modulator of the αCurrent research in pharmacology and drug discovery · 2023Article
- The Pharmacological Effects of Phenylephrine are Indirect, Mediated by Noradrenaline Release from the Cytoplasm.Neurochemical research · 2022Article
- The Pharmacological Effects of Phenylephrine are Indirect, Mediated by Noradrenaline Release from the Cytoplasm.Neurochemical research · 2022Article
- The signaling and selectivity of α-adrenoceptor agonists for the human α2A, α2B and α2C-adrenoceptors and comparison with human α1 and β-adrenoceptors.Pharmacology research & perspectives · 2022Article
- Pharmacophore-guided Virtual Screening to Identify New βMolecular informatics · 2022Article
- The selectivity of α-adrenoceptor agonists for the human α1A, α1B, and α1D-adrenoceptors.Pharmacology research & perspectives · 2021Article
- Targeting Adrenergic Receptors in Metabolic Therapies for Heart Failure.International journal of molecular sciences · 2021Review
- αJournal of receptor and signal transduction research · 2021Article
- Current Developments on the Role of αFrontiers in cell and developmental biology · 2021Review
- αFrontiers in pharmacology · 2020Review
- Updates in the function and regulation of αBritish journal of pharmacology · 2019Review
- What makes the αBritish journal of pharmacology · 2019Review
- Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology.Neuropharmacology · 2019Article
- GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures.Nature reviews. Drug discovery · 2019Review
- Factors influencing biased agonism in recombinant cells expressing the human αBritish journal of pharmacology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAgonists acting at GPCRs promote biased signalling via Gα or Gβγ subunits, GPCR kinases and β-arrestins. Since the demonstration of biased agonism has implications for drug discovery, it is essential to consider confounding factors contributing to bias. We have examined bias at human α EXPERIMENTAL APPROACH: Intracellular Ca KEY
resultsNoradrenaline, phenylephrine, methoxamine and A61603 increased Ca CONCLUSION AND IMPLICATIONS: We have shown that while adrenergic agonists display bias at human α
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.