ReviewCurrent environmental health reports2017
Outdoor Ambient Air Pollution and Neurodegenerative Diseases: the Neuroinflammation Hypothesis.
Review in Current environmental health reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 4 syntheses or guidelines pooled it, 224 citations in OpenAlex.
- Air pollution: a latent key driving force of dementia.BMC public health · 2024Pooled it
- The short-term effect of ambient particulate matter on suicide death.Environmental health : a global access science source · 2024Pooled it
- Urbanization, air pollution, and water pollution: Identification of potential environmental risk factors associated with amyotrophic lateral sclerosis using systematic reviews.Frontiers in neurology · 2023Pooled it
- Air Pollution and Dementia: A Systematic Review.Journal of Alzheimer's disease : JAD · 2019Pooled it
- Prenatal exposure to environmental stressors alters gut macrophage development and gastrointestinal function of male offspring.Brain, behavior, and immunity · 2026Article
- The Gut-Brain Axis and Neurodegenerative Diseases: From Mechanistic Pathways to Therapeutic Interventions.Probiotics and antimicrobial proteins · 2026Review
- Associations of long-term exposure to source-specific PMEuropean archives of psychiatry and clinical neuroscience · 2026Article
- PMEnvironmental health perspectives · 2026Article
- Air pollution and cognitive outcomes in older adults: a systematic review.Reviews on environmental health · 2026Review
- Neurodegenerative diseases and environmental risk factors: an overview of the available scientific evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Short-Term Impacts of PMGeoHealth · 2026Article
- Exposure to Air Pollutants and Lewy Body and Parkinson Disease-Related Dementias.JAMA network open · 2026Article
- Air pollution and mortality in a University of Michigan amyotrophic lateral sclerosis cohort: a survival analysis.Environmental health : a global access science source · 2026Article
- Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.Neurotoxicity research · 2026Article
- Air pollution mixtures and cognitive outcomes in children: associations with school-age exposure and sex differences.European journal of pediatrics · 2026Article
- Airborne particulate matter and the lung-brain axis: unraveling the neuroinflammatory cascade from alveolar irritation to microglial activation.Journal of neuroinflammation · 2026Review
- Spatial and spectral mapping of traffic-related nanoparticles in hippocampal subregions of an Alzheimer disease model.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Long-Term Exposure to Air Pollution and Risk and Prognosis of Motor Neuron Disease.JAMA neurology · 2026Article
- Article
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewAccumulating research indicates that ambient outdoor air pollution impacts the brain and may affect neurodegenerative diseases, yet the potential underlying mechanisms are poorly understood. RECENT
findingsThe neuroinflammation hypothesis holds that elevation of cytokines and reactive oxygen species in the brain mediates the deleterious effects of urban air pollution on the central nervous system (CNS). Studies in human and animal research document that neuroinflammation occurs in response to several inhaled pollutants. Microglia are a prominent source of cytokines and reactive oxygen species in the brain, implicated in the progressive neuron damage in diverse neurodegenerative diseases, and activated by inhaled components of urban air pollution through both direct and indirect pathways. The MAC1-NOX2 pathway has been identified as a mechanism through which microglia respond to different forms of air pollution, suggesting a potential common deleterious pathway. Multiple direct and indirect pathways in response to air pollution exposure likely interact in concert to exert CNS effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.