ArticleInfection2017
Environmental pollution with antimicrobial agents from bulk drug manufacturing industries in Hyderabad, South India, is associated with dissemination of extended-spectrum beta-lactamase and carbapenemase-producing pathogens.
Article in Infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 203 citations in OpenAlex.
- Facilitators for establishing a home-based medicine reverse logistic system in low- and middle-income countries - a scoping review.Frontiers in pharmacology · 2025Pooled it
- Predicted no effect concentrations of antifungals for wastewater management and agricultural use.Frontiers in toxicology · 2026Review
- 'Mind the gaps': stakeholder perspectives on addressing antimicrobial resistance in the environment in the Indian context.Global health action · 2025Article
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- Antibiotic contaminants and their impact in Gingee River, Puducherry: insights from SPE-UPLC-MS/MS and zebrafish study.Toxicology research · 2024Article
- Antibiotic disposal challenges in India: investigating causes and effects.Environmental monitoring and assessment · 2024Review
- Practical Lessons on Antimicrobial Therapy for Critically Ill Patients.Antibiotics (Basel, Switzerland) · 2024Review
- Mapping the scarcity of data on antibiotics in natural and engineered water environments across India.Frontiers in antibiotics · 2024Review
- Detection and Characterization of Carbapenemase-ProducingAntibiotics (Basel, Switzerland) · 2023Article
- High-level Colonization With Antibiotic-Resistant Enterobacterales Among Individuals in a Semi-Urban Setting in South India: An Antibiotic Resistance in Communities and Hospitals (ARCH) Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Rectal colonization is predictive for surgical site infections with multidrug-resistant bacteria in abdominal surgery.Langenbeck's archives of surgery · 2023Article
- Prevalence of Antibiotic-Resistant Pathogenic Bacteria and Level of Antibiotic Residues in Hospital Effluents in Selangor, Malaysia: Protocol for a Cross-sectional Study.JMIR research protocols · 2023Article
- Treatment and disposal practices of pharmaceutical effluent containing potential antibiotic residues in two states in India and perceptions of various stakeholders on contribution of pharmaceutical effluent to antimicrobial resistance: a qualitative study.Journal of pharmaceutical policy and practice · 2023Article
- The Effect of Quinolones on Common DuckweedInternational journal of environmental research and public health · 2023Article
- Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains.Nature microbiology · 2023Article
- Detection of Emerging Pollutants Using Aptamer-Based Biosensors: Recent Advances, Challenges, and Outlook.Biosensors · 2022Review
- Phylogenomic analysis of a metagenome-assembled genome indicates a new taxon of an anoxygenic phototroph bacterium in the family Chromatiaceae and the proposal of "Candidatus Thioaporhodococcus" gen. nov.Archives of microbiology · 2022Article
- One Health approaches adapted in low resource settings to address antimicrobial resistance.Science in One Health · 2022Review
- The occurrence of antimicrobial residues and antimicrobial resistance genes in urban drinking water and sewage in Southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Advocacy for Responsible Antibiotic Production and Use.Antibiotics (Basel, Switzerland) · 2022Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHigh antibiotic and antifungal concentrations in wastewater from anti-infective drug production may exert selection pressure for multidrug-resistant (MDR) pathogens. We investigated the environmental presence of active pharmaceutical ingredients and their association with MDR Gram-negative bacteria in Hyderabad, South India, a major production area for the global bulk drug market.
methodsFrom Nov 19 to 28, 2016, water samples were collected from the direct environment of bulk drug manufacturing facilities, the vicinity of two sewage treatment plants, the Musi River, and habitats in Hyderabad and nearby villages. Samples were analyzed for 25 anti-infective pharmaceuticals with liquid chromatography-tandem mass spectrometry and for MDR Gram-negative bacteria using chromogenic culture media. In addition, specimens were screened with PCR for bla
resultsAll environmental specimens from 28 different sampling sites were contaminated with antimicrobials. High concentrations of moxifloxacin, voriconazole, and fluconazole (up to 694.1, 2500, and 236,950 µg/L, respectively) as well as increased concentrations of eight other antibiotics were found in sewers in the Patancheru-Bollaram industrial area. Corresponding microbiological analyses revealed an extensive presence of extended-spectrum beta-lactamase and carbapenemase-producing Enterobacteriaceae and non-fermenters (carrying mainly bla
conclusionsInsufficient wastewater management by bulk drug manufacturing facilities leads to unprecedented contamination of water resources with antimicrobial pharmaceuticals, which seems to be associated with the selection and dissemination of carbapenemase-producing pathogens. The development and global spread of antimicrobial resistance present a major challenge for pharmaceutical producers and regulatory agencies.
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